Publication:
Thymic tumors and results of radiotherapy

dc.contributor.authorSarıhan, Süreyya
dc.contributor.authorBayram, Ahmet Sami
dc.contributor.authorGebitekin, Cengiz
dc.contributor.authorYerci, Ömer
dc.contributor.authorSığırlı, Deniz
dc.contributor.buuauthorSARIHAN, SÜREYYA
dc.contributor.buuauthorBAYRAM, AHMET SAMİ
dc.contributor.buuauthorGEBİTEKİN, CENGİZ
dc.contributor.buuauthorYERCİ, ÖMER
dc.contributor.buuauthorSIĞIRLI, DENİZ
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
dc.contributor.orcid0000-0003-4816-5798
dc.contributor.orcid0000-0003-0684-0900
dc.contributor.researcheridJCE-0097-2023
dc.contributor.researcheridABB-7580-2020
dc.contributor.researcheridAAH-4970-2021
dc.contributor.researcheridAAA-7472-2021
dc.contributor.researcheridAAE-1069-2022
dc.date.accessioned2024-09-25T05:44:32Z
dc.date.available2024-09-25T05:44:32Z
dc.date.issued2018-03-01
dc.description.abstractAim: The aim of this study was to evaluate thymic epithelial tumors (TETs) for treatment outcomes and prognostic factors on survival.Background: TETs are very rare neoplasms and multidisciplinary approach is recommended according to prognostic factors.Materials and methods: Between 1995 and 2013, 31 patients were treated with median 5400 cGy (range: 1620-6596 cGy) radiotherapy (RT). Eleven patients received adjuvant or concurrent chemotherapy. There were 25 thymomas, 4 thymic carcinomas and 2 thymic neuroendocrin carcinomas. According to Masaoka, staging and WHO classification, cases were divided to good (n: 10), moderate (n: 9) and poor (n: 12) prognostic risk groups. Survival was calculated from diagnosis.Results: In January 2016, 22 cases were alive with median 51.5 months (range: 2-170.5) follow-up. Recurrences were observed in 29% of patients in median 29.5 months (range: 6.5-105). Local control, mean overall (OS) and disease-free survival (DFS) rates were 86%, 119 and 116 months, respectively. There was a significant difference for RO vs. R+ resection (81% vs. 43%, p = 0.06, and 69% vs. 46%, p = 0.05), Masaoka stage I-II vs. III-IV (75% vs. 52%, p = 0.001, and 75% vs. 37%, p < 0.001), and also prognostic risk groups (100% vs. 89% vs. 48%, p = 0.003, and 100% vs. 87% vs. 27%, p = 0.004) in terms of 5-year OS and DFS, respectively.Conclusion: In our study, prognostic risk stratification was shown to be a significant predictor of survival. There is a need to investigate subgroups that may or may not benefit from adjuvant RT. (C) 2017 Greater Poland Cancer Centre. Published by Elsevier Sp. z o.o. All rights reserved.
dc.identifier.doi10.1016/j.rpor.2017.12.002
dc.identifier.endpage104
dc.identifier.issn1507-1367
dc.identifier.issue2
dc.identifier.startpage97
dc.identifier.urihttps://doi.org/10.1016/j.rpor.2017.12.002
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1507136717301037?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11452/45173
dc.identifier.volume23
dc.identifier.wos000427797200005
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherVia Medica
dc.relation.journalReports of Practical Oncology and Radiotherapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEpithelial tumors
dc.subjectPostoperative radiotherapy
dc.subjectRadiation-therapy
dc.subjectSurgical resection
dc.subjectStaging system
dc.subjectThymoma
dc.subjectClassification
dc.subjectComplications
dc.subjectIrradiation
dc.subjectCarcinomas
dc.subjectOncology
dc.subjectRadiology, nuclear medicine & medical imaging
dc.titleThymic tumors and results of radiotherapy
dc.typeArticle
dspace.entity.typePublication
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