Angiogenesis modulation by arachidonic acid-derived lipids: Positive and negative regulators of angiogenesis

Abstract

Arachidonic acid-derived lipids such as 15 deoxy-PGJ2 or 15 epi-lipoxin A4 have been shown to be potent anti-angiogenesis agents regardless of the angiogenesis stimulus. Other arachidonic acid-derived mediators differentially stimulate angiogenesis and the balance among the different arachidonic acid metabolites along their interactions might play an important role in angiogenesis hemostasis in various angiogenesis-associated disorders.