Publication:
CDP-choline and its endogenous metabolites, cytidine and choline, promote the nerve regeneration and improve the functional recovery of injured rat sciatic nerves

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dc.contributor.authorUlus, İsmail Hakkı
dc.contributor.buuauthorArslan, Erhan
dc.contributor.buuauthorKocaeli, Hasan
dc.contributor.buuauthorBekar, Ahmet
dc.contributor.buuauthorTolunay, Şahsine
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentNöroşirürji Ana Bilim Dalı
dc.contributor.departmentPatoloji Ana Bilim Dalı
dc.contributor.researcheridAAI-1612-2021
dc.contributor.scopusid7004957314
dc.contributor.scopusid6603500567
dc.contributor.scopusid6603677218
dc.contributor.scopusid6602604390
dc.date.accessioned2021-12-31T12:56:10Z
dc.date.available2021-12-31T12:56:10Z
dc.date.issued2011-09
dc.description.abstractObjective: Topical cytidine-5'-diphosphocholine (CDP-choline) has been shown to improve the functional recovery and promote the nerve regeneration of injured sciatic nerves in rats. The aims of this study were to test whether CDP-choline was effective at promoting nerve healing when the surgery to repair an injury was delayed and to determine whether the cytidine and/or the choline moieties of CDP-choline contribute to its beneficial actions. Methods: One hundred and fifty Sprague-Dawley rats underwent a surgical procedure that involved damaging the right sciatic nerve and suturing the epineurium. The injured sciatic nerve was either repaired immediately (on the first day) or on the third day after surgery. Rats were assigned to one of five groups and received a topical application of either 0.4 ml of saline (control) or 0.4 ml of 100 mu M CDP-choline, cytidine, choline, or cytidine+choline. Results: The sciatic function index (SFI) of the rats in both groups (those who had their nerve repair immediately versus those on day 3) improved gradually by 4, 8, and 12 weeks after surgery. The percentage recovery in SFI score was significantly higher in rats treated with CDP-choline or cytidine+choline at all time points. Axon count increased by similar to 50% in rats treated either with CDPcholine or cytidine+choline. Treatment with CDP-choline or cytidine+choline reduced scar formation and decreased nerve adherence when the sciatic nerve was repaired immediately, and rats treated with CDPcholine or cytidine+choline had better axonal organization than control rats. Treatment with choline or cytidine alone led to a less marked improvement in SFI score and failed to increase axon count. Conclusion: Our results demonstrate that CDP-choline, as well as the combination of its metabolites, cytidine+choline, improves the functional recovery and promotes the regeneration of injured sciatic nerves treated with immediate or delayed surgical repair in rats.
dc.identifier.citationAslan, E. vd. (2011). "CDP-choline and its endogenous metabolites, cytidine and choline, promote the nerve regeneration and improve the functional recovery of injured rat sciatic nerves". Neurological Research, 33(7), 766-773.
dc.identifier.endpage773
dc.identifier.issn0161-6412
dc.identifier.issue7
dc.identifier.pubmed21756558
dc.identifier.scopus2-s2.0-79960488003
dc.identifier.startpage766
dc.identifier.urihttps://doi.org/10.1179/1743132811Y.0000000004
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.1179/1743132811Y.0000000004
dc.identifier.urihttp://hdl.handle.net/11452/23797
dc.identifier.volume33
dc.identifier.wos000292591700014
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.collaborationYurt içi
dc.relation.journalNeurological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNeurosciences & neurology
dc.subjectCiticoline
dc.subjectPeripheral nerve
dc.subjectScarring
dc.subjectNicotinic acetylcholine-receptors
dc.subjectPlus docosahexaenoic acid
dc.subjectAcute ischemic-stroke
dc.subjectPheochromocytoma cells
dc.subjectBrain-injury
dc.subjectCiticoline
dc.subjectUridine
dc.subjectInvolvement
dc.subjectSurgery
dc.subjectModel
dc.subject.emtreeCholine
dc.subject.emtreeCiticoline
dc.subject.emtreeCytidine
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeAnimal tissue
dc.subject.emtreeArticle
dc.subject.emtreeControlled study
dc.subject.emtreeDrug efficacy
dc.subject.emtreeFemale
dc.subject.emtreeFunctional assessment
dc.subject.emtreeHistopathology
dc.subject.emtreeNerve fiber growth
dc.subject.emtreeNerve injury
dc.subject.emtreeNerve regeneration
dc.subject.emtreeNonhuman
dc.subject.emtreeRat
dc.subject.emtreeScar formation
dc.subject.emtreeSciatic nerve
dc.subject.emtreeTreatment duration
dc.subject.emtreeTreatment response
dc.subject.meshAdministration, cutaneous
dc.subject.meshAnimals
dc.subject.meshCholine
dc.subject.meshCytidine
dc.subject.meshCytidine diphosphate choline
dc.subject.meshDisease models, animal
dc.subject.meshFemale
dc.subject.meshNerve regeneration
dc.subject.meshNeuroprotective agents
dc.subject.meshRats
dc.subject.meshRats, sprague-dawley
dc.subject.meshRecovery of function
dc.subject.meshSciatic neuropathy
dc.subject.meshTrauma severity indices
dc.subject.scopusCiticoline; Neuroprotective Agents; Glycerylphosphorylcholine
dc.subject.wosClinical neurology
dc.subject.wosNeurosciences
dc.titleCDP-choline and its endogenous metabolites, cytidine and choline, promote the nerve regeneration and improve the functional recovery of injured rat sciatic nerves
dc.typeArticle
dc.wos.quartileQ3 (Clinical neurology)
dc.wos.quartileQ4 (Neurosciences)
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Nöroşirürji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Patoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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