Publication:
Preoperative parathyroid hormone levels are correlated with parathyroid adenoma volume and bone mineral density but not serum calcium levels

dc.contributor.authorDuran, Cevdet
dc.contributor.buuauthorKıyıcı, Sinem Küçüksaraç
dc.contributor.buuauthorCander, Soner
dc.contributor.buuauthorGül, Özen Öz
dc.contributor.buuauthorSığırlı, Deniz
dc.contributor.buuauthorÜnal, Oğuz Kaan
dc.contributor.buuauthorSaraydaroǧlu, Özlem
dc.contributor.buuauthorErsoy, Canan
dc.contributor.buuauthorTuncel, Ercan
dc.contributor.buuauthorErtürk, Erdinç
dc.contributor.buuauthorİmamoğlu, Şazi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentPatoloji Ana Bilim Dalı
dc.contributor.departmentEndokrinoloji ve Metabolizma Ana Bilim Dalı
dc.contributor.departmentBiyoistatistik Ana Bilim Dalı
dc.contributor.researcheridAAJ-6536-2021
dc.contributor.researcheridAAH-9701-2021
dc.contributor.researcheridAAI-1005-2021
dc.contributor.researcheridAAA-7472-2021
dc.contributor.researcheridAAH-8861-2021
dc.contributor.scopusid12753880400
dc.contributor.scopusid25027068600
dc.contributor.scopusid26040787100
dc.contributor.scopusid24482063400
dc.contributor.scopusid36716200600
dc.contributor.scopusid15074395500
dc.contributor.scopusid6701485882
dc.contributor.scopusid7006929833
dc.contributor.scopusid7005488796
dc.contributor.scopusid6602297533
dc.date.accessioned2022-11-09T13:24:42Z
dc.date.available2022-11-09T13:24:42Z
dc.date.issued2011-06
dc.description.abstractAim. The aim of this study was to determine the relationship between biochemical parameters, parathyroid adenoma volume, and bone mineral density with respect to intact parathyroid hormone (iPTH) levels in patients with primary hyperparathyroidism. Methods. Data were collected retrospectively from patients with primary hyperparathyroidism who were diagnosed and followed in our clinic between 2005 and 2008. Forty-eight (female/male=42/6) patients with a mean age of 52.8 +/- 13.1 years were enrolled into the study. Results. Bone pain was the most common presenting feature, seen in 41.7% of patients, while 29.1% of patients were asymptomatic. The mean serum calcium and iPTH concentrations were 2.9 +/- 0.6 mmol/L and 657.1 +/- 682 ng/L, respectively. The mean total Z/T scores of dual-energy X-ray absorptiometry (DEXA) scan at the femur and lumbar spine were -0.4 +/- 1.6/-1.0 +/- 1.7 and -1.4 +/- 1.6/-2.2 +/- 1.5, respectively. Preoperative iPTH levels were correlated with serum phosphate (r=-0.412, P=0.005), alkaline phosphatase (r=0.698, P=0.0001), and femur (r=-0.402, P=0.020) and lumbar spine total Z scores (r=-0.441, P=0.013), whereas parathyroid adenoma volume was correlated with iPTH (r=0.367, P=0.036) and alkaline phosphatase (r=0.570, P=0.001). There was no correlation between iPTH, serum calcium levels and total T scores at the femur and lumbar spine. After excluding patients with 25-OHD insufficiency, there was still no correlation between serum iPTH and calcium levels. Parathyroid adenoma volume, serum iPTH and calcium levels were also not different between patients with and without 25-OHD insufficiency. Conclusion. These results suggest that serum iPTH level may be useful in predicting parathyroid adenoma volume and it is also well correlated with femur and lumbar spine Z scores.
dc.identifier.citationKıyıcı, S. vd. (2011). "Preoperative parathyroid hormone levels are correlated with parathyroid adenoma volume and bone mineral density but not serum calcium levels". Minerva Endocrinologica, 36(2), 123-128.
dc.identifier.endpage128
dc.identifier.issn0391-1977
dc.identifier.issn1827-1634
dc.identifier.issue2
dc.identifier.pubmed21519321
dc.identifier.scopus2-s2.0-79960621593
dc.identifier.startpage123
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/21519321/
dc.identifier.urihttp://hdl.handle.net/11452/29441
dc.identifier.volume36
dc.identifier.wos000290776400004
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherEdizioni Minerva Medica
dc.relation.collaborationYurt içi
dc.relation.journalMinerva Endocrinologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEndocrinology & metabolism
dc.subjectHyperparathyroidism, primary
dc.subjectAdenoma
dc.subjectParathyroid hormone
dc.subjectPrimary hyperparathyroidism
dc.subjectLaboratory findings
dc.subjectWeight
dc.subjectUltrasonography
dc.subject.emtree25 hydroxy Vitamin D
dc.subject.emtreeAlkaline phosphatase
dc.subject.emtreeCalcium
dc.subject.emtreeParathyroid hormone
dc.subject.emtreePhosphate
dc.subject.emtreeUnclassified drug
dc.subject.emtreeVitamin D
dc.subject.emtreeAdult
dc.subject.emtreeAlkaline phosphatase blood level
dc.subject.emtreeArticle
dc.subject.emtreeBone density
dc.subject.emtreeBone pain
dc.subject.emtreeCalcium blood level
dc.subject.emtreeClinical article
dc.subject.emtreeClinical feature
dc.subject.emtreeDual energy X ray absorptiometry
dc.subject.emtreeFemale
dc.subject.emtreeFemur
dc.subject.emtreeHuman
dc.subject.emtreeLaboratory test
dc.subject.emtreeLumbar spine
dc.subject.emtreeMale
dc.subject.emtreeParathyroid adenoma
dc.subject.emtreeParathyroid hormone blood level
dc.subject.emtreePhosphate blood level
dc.subject.emtreePreoperative period
dc.subject.emtreePrimary hyperparathyroidism
dc.subject.emtreeTumor volume
dc.subject.emtreeVitamin D deficiency
dc.subject.meshAbsorptiometry, photon
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshBone density
dc.subject.meshCalcium
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle aged
dc.subject.meshPain
dc.subject.meshParathyroid hormone
dc.subject.meshParathyroid neoplasms
dc.subject.meshRetrospective studies
dc.subject.meshYoung adult
dc.subject.scopusPrimary Hyperparathyroidism; Parathyroid Neoplasms; Methoxy Isobutyl Isonitrile Technetium Tc 99M
dc.subject.wosEndocrinology & metabolism
dc.titlePreoperative parathyroid hormone levels are correlated with parathyroid adenoma volume and bone mineral density but not serum calcium levels
dc.typeArticle
dc.wos.quartileQ4
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Endokrinoloji ve Metabolizma Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Biyoistatistik Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Patoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

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