The diagnostic and prognostic utility of complete blood count (CBC)-derived indices in dogs with sepsis caused by canine parvoviral infection

Abstract

This study aimed to evaluate the diagnostic and prognostic value of complete blood count (CBC)-derived indices incorporating red blood cell (RBC) and platelet (PLT) parameters in dogs that met the criteria for sepsis due to canine parvovirosis (CP). Fifty-two client-owned dogs with CP and ten healthy controls were enrolled in this study. CBC-derived indices, along with serum CRP and albumin concentrations, were evaluated before (T0) and after treatment (T1 and T3). Dogs meeting the criteria for sepsis exhibited statistically significantly higher RDW/L (P < 0.001), MCV/L (P < 0.001), MPV/L (P < 0.001), PLT/L (P < 0.001), PCT/L (P < 0.001), and PDW/L ratios (P < 0.001) compared to the control group. Receiver operating characteristic curve analysis revealed high diagnostic and prognostic performance for MCV/L (AUC: >0.949) and MPV/L (AUC: >0.961). In conclusion, CBC-derived indices incorporating RBC and PLT parameters can provide useful information about the diagnosis and prognosis in dogs with sepsis produced by parvovirus. These findings, if corroborated in larger studies, would support their integration into clinical practice to enhance the early detection and risk stratification in canine sepsis.