Publication:
The relationship between Cardiotrophin-1 and Troponin-I in coronary arterial bypass grafting on the beating heart: A prospective study

dc.contributor.authorÇalışkan, Serhat
dc.contributor.authorBeşli, Feyzullah
dc.contributor.authorYıldırım, Ahmet
dc.contributor.authorGüngören, Fatih
dc.contributor.authorAlışır, Mehmet Fethi
dc.contributor.authorPolat, Ufuk
dc.contributor.authorÖzdemir, Bülent
dc.contributor.authorBiçer, Murat
dc.contributor.buuauthorÇalışkan, Serhat
dc.contributor.buuauthorYıldırım, Ahmet
dc.contributor.buuauthorGüngören, Fatih
dc.contributor.buuauthorPolat, Ufuk
dc.contributor.buuauthorÖZDEMİR, BÜLENT
dc.contributor.buuauthorBİÇER, MURAT
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentKalp Damar Cerrahisi Ana Bilim Dalı
dc.contributor.orcid0000-0003-4411-8185
dc.contributor.orcid0000-0002-0815-9505
dc.contributor.researcheridAAA-3163-2021
dc.contributor.researcheridABC-2231-2020
dc.contributor.researcheridAAC-9352-2021
dc.contributor.researcheridERK-8925-2022
dc.contributor.researcheridJTI-0902-2023
dc.contributor.researcheridDLY-6718-2022
dc.date.accessioned2024-08-06T07:48:47Z
dc.date.available2024-08-06T07:48:47Z
dc.date.issued2015-08-01
dc.description.abstractObjective: Cardiotrophin-1 (CT-1) is closely associated with many cardiovascular diseases, such as hypertension, myocardial infarction (MI), and heart failure, and exhibits a cardioprotective effect in ischemia-reperfusion injury. The aim of this study was to evaluate the relationship between CT-1 and Troponin-I (Tn-I) in off-pump coronary artery bypass (OPCAB) grafting on the beating heart.Methods: Seventy-eight patients (mean age 60.8 +/- 9.7 years, 79.5% male) undergoing elective OPCAB surgery were included in this study undertaken between July 1, 2012 and July 1, 2013 in the Department of Cardiology and Cardiac Surgery, University School of Medicine Hospital. Venous blood samples were collected 5 minutes before OPCAB surgery and 6 hours after surgery. Plasma CT-1 levels were measured using the ELISA method.Results: Compared to the preoperative period, Tn-I and CT-1 values were higher in the postoperative period [0.255 ng/mL (0.030-0.430) versus 0.045 ng/mL (0.005-0.090), P < .001; and 33.7 pg/mL (15.8-98.5) versus 8.7 pg/mL (0.68-25.4), P <. 001]. There was also an elevation in white blood cells, aspartate aminotransferase, creatine kinase (CK), and creatine kinase MB (CK-MB) values, as well as a decrease in hemoglobin values (P < .001). When a correlation analysis for postoperative CT-1 was performed, there was a significant positive correlation between postoperative CK, CK-MB, and Tn-I levels (r = 0.250, P < .027; r = 0.270, P =.017; and r = 0.241, P < .034).Conclusion: CT-1 was found to be associated with Tn-I, which is used to detect myocardial damage after OPCAB surgery. CT-1 may also be used to detect myocardial damage.
dc.identifier.doi10.1532/hsf.1386
dc.identifier.endpageE150
dc.identifier.issn1098-3511
dc.identifier.issue4
dc.identifier.startpageE146
dc.identifier.urihttps://doi.org/10.1532/hsf.1386
dc.identifier.urihttps://journal.hsforum.com/index.php/HSF/article/view/1386
dc.identifier.urihttps://hdl.handle.net/11452/43744
dc.identifier.volume18
dc.identifier.wos000370850300006
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherForum Multimedia Publishing
dc.relation.journalHeart Surgery Forum
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPerioperative myocardial-infarction
dc.subjectBrain natriuretic peptide
dc.subjectClinical-significance
dc.subjectPump
dc.subjectExpression
dc.subjectProtects
dc.subjectFailure
dc.subjectCardiovascular system & cardiology
dc.subjectSurgery
dc.titleThe relationship between Cardiotrophin-1 and Troponin-I in coronary arterial bypass grafting on the beating heart: A prospective study
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Kardiyoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Kalp Damar Cerrahisi Ana Bilim Dalı
relation.isAuthorOfPublicationc653a7c1-4ead-46da-83e5-de7378a3726d
relation.isAuthorOfPublication10e6b267-dba0-4030-a6f8-a296856cf7ba
relation.isAuthorOfPublication.latestForDiscoveryc653a7c1-4ead-46da-83e5-de7378a3726d

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