Publication:
Muscimol injection into the lateral hypothalamus inhibits the hypotension and bradycardia caused by somato-visceral nociception

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dc.contributor.authorLevendusky, Mark C.
dc.contributor.authorMillington, William R.
dc.contributor.buuauthorGöktalay, Gökhan
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıbbi Farmakoloji Ana Bilim Dalı
dc.contributor.orcid0000-0001-6261-4233
dc.contributor.researcheridAAH-1448-2021
dc.contributor.scopusid6508023759
dc.date.accessioned2023-11-23T06:24:51Z
dc.date.available2023-11-23T06:24:51Z
dc.date.issued2004-12-10
dc.description.abstractThis study investigated whether the lateral hypothalamus (LH) contributes to the depressor response evoked by somato-visceral nociception. Lidocame (2%; 0.1, 0.3 or 1.0 mul) or muscimol (0.34 nmol; 0.5 mul) was microinjected into the rostral LH of halothane-anesthetized rats bilaterally and somato-visceral nociception was induced 2 min later by injecting 5% acetic acid (0.5 ml) intraperitoneally. Lidocaine and muscimol inhibited the hypotension and bradycardia caused by somato-visceral nociception significantly without affecting cardiovascular function in normotensive animals.
dc.identifier.citationGöktalay, G. vd. (2004). “Muscimol injection into the lateral hypothalamus inhibits the hypotension and bradycardia caused by somato-visceral nociception”. Brain Research , 1029(1), 124-130.
dc.identifier.endpage130
dc.identifier.issn0006-8993
dc.identifier.issue1
dc.identifier.pubmed15533324
dc.identifier.scopus2-s2.0-7744237862
dc.identifier.startpage124
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2004.09.029
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0006899304015707
dc.identifier.urihttp://hdl.handle.net/11452/34986
dc.identifier.volume1029
dc.identifier.wos000225481700015
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier
dc.relation.collaborationYurt dışı
dc.relation.journalBrain Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNeurosciences and neurology
dc.subjectLateral hypothalamus
dc.subjectVisceral nociception
dc.subjectPain
dc.subjectGABA receptor
dc.subjectMuscimol
dc.subjectCardiovascular regulation
dc.subjectMidbrain periaqueductal gray
dc.subjectAnterior hypothalamus
dc.subjectEfferent projections
dc.subjectFos
dc.subjectArea
dc.subjectImmunoreactivity
dc.subjectOrganization
dc.subjectStimulation
dc.subjectNucleus
dc.subjectNeurons
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeArticle
dc.subject.emtreeBradycardia
dc.subject.emtreeCardiovascular function
dc.subject.emtreeControlled study
dc.subject.emtreeDrug effect
dc.subject.emtreeEvoked somatosensory response
dc.subject.emtreeHypotension
dc.subject.emtreeHypothalamus
dc.subject.emtreeMale
dc.subject.emtreeMicroinjection
dc.subject.emtreeNociception
dc.subject.emtreeNonhuman
dc.subject.emtreePriority journal
dc.subject.emtreeRat
dc.subject.emtree4 aminobutyric acid a receptor stimulating agent
dc.subject.emtreeAcetic acid
dc.subject.emtreeLidocaine
dc.subject.emtreeMuscimol
dc.subject.meshAnimals
dc.subject.meshBradycardia
dc.subject.meshCardiovascular physiology
dc.subject.meshGABA agonists
dc.subject.meshHomocysteine
dc.subject.meshHypotension
dc.subject.meshHypothalamic area, lateral
dc.subject.meshMale
dc.subject.meshMicroinjections
dc.subject.meshMuscimol
dc.subject.meshPain
dc.subject.meshRats
dc.subject.meshRats, sprague-dawley
dc.subject.scopusPeriaqueductal Gray; Animals; Escape Reaction
dc.subject.wosNeurosciences
dc.titleMuscimol injection into the lateral hypothalamus inhibits the hypotension and bradycardia caused by somato-visceral nociception
dc.typeArticle
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Farmakoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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