Impact of extended torsion on ovarian reserve: Experimental torsion-detorsion model in rabbit

Abstract

OBJECTIVE: To evaluate the effect of duration of torsion on ovarian reserve. STUDY DESIGN: Twenty-two female New Zealand rabbits were divided into a sham and 2 study groups. The torsion/detorsion (T/DT) groups had left adnexal torsion for either 3 or 6 hours followed by detorsion. Ovaries were evaluated histologically for follicular damage, and preoperative, predetorsion, and postdetorsion blood samples were drawn from each rabbit to measure antiMiillerian hormone (AMH) levels. RESULTS: Mean primary, small antral, and antral follicle counts were lower in the T/DT groups as compared to the sham group. Primordial, small antral, and antral follicle counts were not different between the 3-hour T/DT and 6-hour T/DT groups. When compared with contralateral ovary, the 6-hour T/DT group had significantly lower follicle count. The 6-hour T/DT group had higher percent change in both predetorsion and postdetorsion AMH levels as compared to the 3-hour T/DT group. CONCLUSION: Although extended time of torsion has negative impact on ovarian reserve, the ovary keeps its viability with functioning follicles after detorsion.