Publication:
Cardiovascular effects of the intracerebroventricular injection of adrenomedullin: Roles of the peripheral vasopressin and central cholinergic systems

dc.contributor.buuauthorÇam, Betül Etöz
dc.contributor.buuauthorİşbil, Naciye Büyükcoşkun
dc.contributor.buuauthorÖzlük, Kasım
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFizyoloji Ana Bilim Dalı
dc.contributor.researcheridAAH-1692-2021
dc.contributor.scopusid24179406800
dc.contributor.scopusid55665951400
dc.contributor.scopusid6602676331
dc.date.accessioned2022-05-25T08:36:23Z
dc.date.available2022-05-25T08:36:23Z
dc.date.issued2012-03
dc.description.abstractOur objective was to investigate in conscious Sprague-Dawley (6-8 weeks, 250-300 g) female rats (N = 7 in each group) the effects of intracerebroventricularly (icv) injected adrenomedullin (ADM) on blood pressure and heart rate (HR), and to determine if ADM and calcitonin gene-related peptide (CGRP) receptors, peripheral V-1 receptors or the central cholinergic system play roles in these cardiovascular effects. Blood pressure and HR were observed before and for 30 min following drug injections. The following results were obtained: 1) icv ADM (750 ng/10 mu L) caused an increase in both blood pressure and HR (Delta MAP = 11.8 +/- 2.3 mmHg and Delta HR = 39.7 +/- 4.8 bpm). 2) Pretreatment with a CGRP receptor antagonist (CGRP(8-37)) and ADM receptor antagonist (ADM(22-52)) blocked the effect of central ADM on blood pressure and HR. 3) The nicotinic receptor antagonist mecamylamine (25 mu g/10 mu L, icv) and the muscarinic receptor antagonist atropine (5 mu g/10 mu L, icv) prevented the stimulating effect of ADM on blood pressure. The effect of ADM on HR was blocked only by atropine (5 mu g/10 mu L, icv). 4) The V-1 receptor antagonist [beta-mercapto-beta-beta-cyclopentamethylenepropionyl(1), O-me-Tyr(2),Arg(8)]-vasopressin (V2255; 10 mu g/kg), that was applied intravenously, prevented the effect of ADM on blood pressure and HR. This is the first study reporting the role of specific ADM and CGRP receptors, especially the role of nicotinic and muscarinic central cholinergic receptors and the role of peripheral V-1 receptors in the increasing effects of icv ADM on blood pressure and HR.
dc.identifier.citationÇam, E. B. vd. (2012). "Cardiovascular effects of the intracerebroventricular injection of adrenomedullin: Roles of the peripheral vasopressin and central cholinergic systems". Brazilian Journal of Medical and Biological Research, 45(3), 250-255.
dc.identifier.endpage255
dc.identifier.issn0100-879X
dc.identifier.issn1414-431X
dc.identifier.issue3
dc.identifier.pubmed22370705
dc.identifier.scopus2-s2.0-84858427547
dc.identifier.startpage250
dc.identifier.urihttps://doi.org/10.1590/S0100-879X2012007500027
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854196/
dc.identifier.urihttp://hdl.handle.net/11452/26682
dc.identifier.volume45
dc.identifier.wos000302556400011
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherAssoc Bras Divulg Cientifica
dc.relation.journalBrazilian Journal of Medical and Biological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitakSBAG-105S508
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLife sciences & biomedicine - other topics
dc.subjectResearch & experimental medicine
dc.subjectAdrenomedullin
dc.subjectBlood pressure
dc.subjectVasopressin
dc.subjectAtropine
dc.subjectMecamylamine
dc.subjectNervous-system
dc.subjectBlood-pressure
dc.subjectReceptors
dc.subjectMechanisms
dc.subjectPeptide
dc.subjectBrain
dc.subjectImmunoreactivity
dc.subjectAcetylcholine
dc.subjectInvolvement
dc.subjectParameters
dc.subjectRattus
dc.subject.emtree(Beta mercapto beta beta cyclopentamethylenepropionyl1, o me tyrosine2,arginine8)vasopressin
dc.subject.emtreeAdrenomedullin
dc.subject.emtreeAdrenomedullin[22-52]
dc.subject.emtreeAtropine
dc.subject.emtreeCalcitonin gene related peptide receptor
dc.subject.emtreeCalcitonin gene related peptide receptor antagonist
dc.subject.emtreeCalcitonin gene related peptide receptor[8-37]
dc.subject.emtreeMecamylamine
dc.subject.emtreeMuscarinic receptor
dc.subject.emtreeNicotinic receptor
dc.subject.emtreeUnclassified drug
dc.subject.emtreeVasopressin derivative
dc.subject.emtreeVasopressin v1 receptor
dc.subject.emtreeAnimal experiment
dc.subject.emtreeArticle
dc.subject.emtreeBlood pressure regulation
dc.subject.emtreeCardiovascular response
dc.subject.emtreeCholinergic stimulation
dc.subject.emtreeDrug mechanism
dc.subject.emtreeDrug receptor binding
dc.subject.emtreeFemale
dc.subject.emtreeHeart rate
dc.subject.emtreeNonhuman
dc.subject.emtreeRat
dc.subject.emtreeReceptor blocking
dc.subject.scopusAdrenomedullin Receptors; Receptor Activity-Modifying Proteins; Calcitonin Receptor Like Receptor
dc.subject.wosBiology
dc.subject.wosMedicine, research & experimental
dc.titleCardiovascular effects of the intracerebroventricular injection of adrenomedullin: Roles of the peripheral vasopressin and central cholinergic systems
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Fizyoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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