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Olea europaea leaf extract and bevacizumab synergistically exhibit beneficial efficacy upon human glioblastoma cancer stem cells through reducing angiogenesis and invasion in vitro

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Tezcan, Gülçin
Taşkapılıoğlu, Mevlut Özgür
Tunca, Berrin
Bekar, Ahmet
Demirci, Hilal
Kocaeli, Hasan
Aksoy, Seçil Ak
Egeli, Ünal
Cecener, Gülşah
Tolunay, Şahsine

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Elsevier

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Patients with glioblastoma multiforme (GBM) that are cancer stem-cell-positive (GSC [+]) essentially cannot benefit from anti-angiogenic or anti-invasive therapy. In the present study, the potential anti-angiogenic and anti-invasive effects of Olea europaea (olive) leaf extract (OLE) were tested using GSC (+) tumours. OLE (2 mg/mL) caused a significant reduction in tumour weight, vascularisation, invasiveness and migration (p = 0.0001, p < 0.001, p = 0.004; respectively) that was associated with reducing the expression of VEGFA, MMP-2 and MMP-9. This effect was synergistically increased in combination with bevacizumab. Therefore, our current findings may contribute to research on drugs that inhibit the invasiveness of GBM.

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Research & experimental medicine, Pharmacology & pharmacy, Angiogenesis, Glioblastoma cancer stem cell, Invasion, MMP2, MMP9, Olea europaea leaf extract, VEGFA, Antiangiogenic therapies, Mesenchymal transition, Antioxidant activity, Olive oil, Oleuropein, Expression, Polyphenols, Gata6, Proliferation, Microrna-153

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Tezcan, G. vd. (2017). ''Olea europaea leaf extract and bevacizumab synergistically exhibit beneficial efficacy upon human glioblastoma cancer stem cells through reducing angiogenesis and invasion in vitro''. Biomedicine and Pharmacotherapy, 90, 713-723.

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