Yayın: Glutathione S-Transferase activity in tissues of rats exposed to fenarimol
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Dosyalar
Tarih
2021-01-01
Kurum Yazarları
Yazarlar
Özçelebi, Halime
Arı, Ferda
Dere, Egemen
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayımcı
Inst Tecnologia Parana
Özet
The unconscious use of pesticides causes various adverse effects on non-target organisms, including humans. Enzymes that control metabolism become the target of the pesticide and the organs are damaged due to toxic effects. Glutathione s-transferase (GST, EC 2.5.1.18), an important enzyme of the detoxification mechanism and antioxidant defense system, can be affected by such toxic substances. Therefore, the effect of fenarimol on GST enzyme activity was investigated in our study. For this, 200 mg/kg fenarimol was administered intraperitoneally to male and female rats at different periods (2, 4, 8, 16, 32, 64 and 72 hours). After application, GST enzyme activity was analysed in the liver, kidney, brain and small intestine tissues of the rats. According to our results, activation (liver, kidney, small intestine) or inhibition (brain) of the generally GST enzyme was observed in the tissues of rats exposed to fenarimol. It is thought that the increase and/or decrease in this enzyme activity may be the cause of the toxic effect of fenarimol.
Açıklama
Anahtar kelimeler
Early-life stages, Insecticide resistance, Oxidative stress, Gene-expression, Cyprinus-carpio, In-vitro, Fungicide, Pesticides, Toxicity, Genotoxicity, Pesticide, Fungicide, Fenarimol, Glutathione s-transferase, Science & technology, Life sciences & biomedicine, Biology