Publication: Small arterial elasticity predicts the extent of coronary artery disease: Relationship with serum uric acid
Date
Authors
Fazlıoğlu, Murat
Şentürk, Tunay
Kumbay, Ethem
Kaderli, Aysel Aydın
Yılmaz, Yusuf
Özdemir, Bülent
Baran, İbrahim
Aydınlar, Ali
Authors
Advisor
Language
Type
Publisher:
Elsevier Ireland
Journal Title
Journal ISSN
Volume Title
Abstract
Background: Arterial elasticity has been previously linked to atherosclerotic vascular disease states. Serum uric acid level has been recently associated with increased arterial stiffness, but to what extent serum uric acid reflects angiographic coronary artery status and vessel compliance remains to be established. In this study we aimed to evaluate the association of arterial elasticity indexes, serum uric acid and the presence and extent of angiographic coronary artery disease (CAD) in patients with chronic stable angina.
Methods: One hundred and eight consecutive patients attending for elective coronary angiography were investigated. The severity of CAD was expressed using the Gensini score. Quantitative analysis of the arterial elasticity was performed by applanation tonometry. Serum uric acid was measured in all participants. Stepwise multiple linear regression analysis was used to identify the independent correlates of the Gensini score.
Results: After adjustment for age, gender, common cardiac risk factors and cardiovascular drugs, small artery elasticity index (SAEI) (p < 0.001) and Serum uric acid (p < 0.001) were independently correlated with the severity of CAD. Stepwise multiple linear regression analysis was also used to identify independent correlates of the SAEI. Serum uric acid emerged as the only independent correlate of SAEI (P < 0.001).
Conclusions: SAEI independently reflects the extent of CAD in patients with chronic stable angina. This relationship is chiefly mediated by serum uric acid. Our data add to the growing evidence that serum uric acid may be a marker of arterial stiffness and atherosclerotic burden.
Description
Source:
Keywords:
Keywords
Arterial stiffness, Coronary artery disease, Endothelial dysfunction, Uric acid, Heart-disease, Cardiovascular-disease, Risk, Association, Stiffness, Marker, Cardiovascular system & cardiology
Citation
Fazlıoğlu, M. vd. (2009). "Small arterial elasticity predicts the extent of coronary artery disease: Relationship with serum uric acid". Atherosclerosis, 202(1), 200-204.