Publication: Immunohistochemical expression of human epidermal growth factor receptor (HER)-4 and prognosis in patients with metastatic breast cancer
dc.contributor.buuauthor | Deligönül, Adem | |
dc.contributor.buuauthor | Evrensel, Türkkan | |
dc.contributor.buuauthor | Avcı, Nilüfer | |
dc.contributor.buuauthor | Uğraş, Nesrin | |
dc.contributor.buuauthor | Türe, Mehmet | |
dc.contributor.buuauthor | Çubukçu, Erdem | |
dc.contributor.buuauthor | Hartavi, Mustafa | |
dc.contributor.buuauthor | Ölmez, Ömer Fatih | |
dc.contributor.buuauthor | Kurt, Ender | |
dc.contributor.buuauthor | Tolunay, Şahsine | |
dc.contributor.buuauthor | Kanat, Özkan | |
dc.contributor.buuauthor | Manavoğlu, Osman | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Tıbbi Onkoloji Ana Bilim Dalı | |
dc.contributor.orcid | 0000-0002-9732-5340 | tr_TR |
dc.contributor.orcid | 0000-0002-5771-7649 | tr_TR |
dc.contributor.researcherid | ESM-4544-2022 | tr_TR |
dc.contributor.researcherid | AAJ-1027-2021 | tr_TR |
dc.contributor.researcherid | CCT-7946-2022 | tr_TR |
dc.contributor.researcherid | AAH-2716-2021 | tr_TR |
dc.contributor.researcherid | ECY-8582-2022 | tr_TR |
dc.contributor.researcherid | ETP-1691-2022 | tr_TR |
dc.contributor.researcherid | CUI-5353-2022 | tr_TR |
dc.contributor.researcherid | DJG-4827-2022 | tr_TR |
dc.contributor.researcherid | DAS-3088-2022 | tr_TR |
dc.contributor.researcherid | AAI-1612-2021 | tr_TR |
dc.contributor.researcherid | CYM-0930-2022 | tr_TR |
dc.contributor.researcherid | FLP-9613-2022 | tr_TR |
dc.contributor.scopusid | 37088030300 | tr_TR |
dc.contributor.scopusid | 6603942124 | tr_TR |
dc.contributor.scopusid | 55390409800 | tr_TR |
dc.contributor.scopusid | 55386535600 | tr_TR |
dc.contributor.scopusid | 6602186133 | tr_TR |
dc.contributor.scopusid | 53986153800 | tr_TR |
dc.contributor.scopusid | 55370753300 | tr_TR |
dc.contributor.scopusid | 26435400000 | tr_TR |
dc.contributor.scopusid | 7006207332 | tr_TR |
dc.contributor.scopusid | 6602604390 | tr_TR |
dc.contributor.scopusid | 55881548500 | tr_TR |
dc.contributor.scopusid | 6602587152 | tr_TR |
dc.date.accessioned | 2024-01-09T07:42:29Z | |
dc.date.available | 2024-01-09T07:42:29Z | |
dc.date.issued | 2016 | |
dc.description.abstract | Purpose: The clinical value of HER4 - a cell surface receptor that belongs to the human epidermal growth factor receptor family - for predicting survival outcomes in patients with breast cancer remains controversial. Herein, we sought to investigate the prognostic significance of HER4 immunohistochemical expression with respect to progression-free survival (PFS) and overall survival (OS) in Turkish patients with metastatic breast cancer (MBC).Methods: MBC patients (N=45; mean age=50.5 +/- 12.7 years) were consecutively enrolled between 2000 and 2006 in the Department of Oncology at the Uludag University Medical Center, Bursa, Turkey. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded sections. The predictive value of HER4 expression was investigated by multivariate analysis after allowance for potential confounders.Results: The mean PFS in the study participants was 11.35 months (range:1-50), whereas the median OS was 22.18 months (range:1-76). The mean PFS in patients with a HER4 immunohistochemical score of 0, 1+, 2+, and 3+ was 11.0 +/- 4.8, 11.3 +/- 7.7, 11.7 +/- 8.1, and 10.4 +/- 7.4 months, respectively (p=0.99). The mean OS in patients with a HER4 score of 0, 1+, 2+, and 3+ was 13.3 +/- 6.8, 25.6 +/- 10.8, 22.9 +/- 10.7, and 13.5 +/- 9.9, months, respectively (p=0.44). The results of multivariate Cox regression analysis indicated that the presence of visceral metastases was the only independent prognostic factor for both OS (HR=3.01, 95% CI=1.56-3.99, p <0.01) and PFS (HR=2.91, 95% CI=1.51-3.78, p <0.01).Conclusion: HER4 immunohistochemical expression is not an independent predictor of OS and PFS in Turkish MBC patients. | en_US |
dc.identifier.citation | Deligönül, A. vd. (2016). "Immunohistochemical expression of human epidermal growth factor receptor (HER)-4 and prognosis in patients with metastatic breast cancer". Journal of BUON, 21(3), 564-569. | en_US |
dc.identifier.endpage | 569 | tr_TR |
dc.identifier.issn | 1107-0625 | |
dc.identifier.issn | 2241-6293 | |
dc.identifier.issue | 3 | tr_TR |
dc.identifier.pubmed | 27569073 | tr_TR |
dc.identifier.scopus | 2-s2.0-84994164404 | tr_TR |
dc.identifier.startpage | 564 | tr_TR |
dc.identifier.uri | https://europepmc.org/article/med/27569073 | |
dc.identifier.uri | https://hdl.handle.net/11452/38882 | |
dc.identifier.volume | 21 | tr_TR |
dc.identifier.wos | 000378978900005 | |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.wos | SCIE | |
dc.language.iso | en | en_US |
dc.publisher | Imprimatur Publications | en_US |
dc.relation.journal | Journal of BUON | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Oncology | en_US |
dc.subject | HER4 | en_US |
dc.subject | Immunochemistry | en_US |
dc.subject | Metastatic breast cancer | en_US |
dc.subject | Prognosis | en_US |
dc.subject | Survival | en_US |
dc.subject | Progesterone-receptor | en_US |
dc.subject | Estrogen-receptor | en_US |
dc.subject | Systemic therapy | en_US |
dc.subject | Bh3-only protein | en_US |
dc.subject | Coactivator | en_US |
dc.subject | ERBB4/HER4 | en_US |
dc.subject | Carcinomas | en_US |
dc.subject | Recurrence | en_US |
dc.subject | HER4/4ICD | en_US |
dc.subject | Family | en_US |
dc.subject.emtree | Anthracycline | en_US |
dc.subject.emtree | Epidermal growth factor receptor 2 | en_US |
dc.subject.emtree | Epidermal growth factor receptor 4 | en_US |
dc.subject.emtree | Estrogen receptor | en_US |
dc.subject.emtree | Progesterone receptor | en_US |
dc.subject.emtree | Taxane derivative | en_US |
dc.subject.emtree | Epidermal growth factor receptor 4 | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Cancer grading | en_US |
dc.subject.emtree | Cancer localization | en_US |
dc.subject.emtree | Cancer prognosis | en_US |
dc.subject.emtree | Clinical article | en_US |
dc.subject.emtree | Female | en_US |
dc.subject.emtree | Follow up | en_US |
dc.subject.emtree | Human | en_US |
dc.subject.emtree | Immunohistochemistry | en_US |
dc.subject.emtree | Metastatic breast cancer | en_US |
dc.subject.emtree | Middle aged | en_US |
dc.subject.emtree | Overall survival | en_US |
dc.subject.emtree | Progression free survival | en_US |
dc.subject.emtree | Protein expression | en_US |
dc.subject.emtree | Retrospective study | en_US |
dc.subject.emtree | Tumor growth | en_US |
dc.subject.emtree | Tumor volume | en_US |
dc.subject.emtree | Turk (people) | en_US |
dc.subject.emtree | Aged | en_US |
dc.subject.emtree | Breast tumor | en_US |
dc.subject.emtree | Chemistry | en_US |
dc.subject.emtree | Immunohistochemistry | en_US |
dc.subject.emtree | Metastasis | en_US |
dc.subject.emtree | Mortality | en_US |
dc.subject.emtree | Pathology | en_US |
dc.subject.emtree | Prognosis | en_US |
dc.subject.emtree | Proportional hazards model | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Breast neoplasms | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Immunohistochemistry | en_US |
dc.subject.mesh | Middle aged | en_US |
dc.subject.mesh | Neoplasm metastasis | en_US |
dc.subject.mesh | Prognosis | en_US |
dc.subject.mesh | Proportional hazards models | en_US |
dc.subject.mesh | Receptor, ErbB-4 | en_US |
dc.subject.scopus | Erbb-3 Receptor; U3-1287; Cancer | en_US |
dc.subject.wos | Oncology | en_US |
dc.title | Immunohistochemical expression of human epidermal growth factor receptor (HER)-4 and prognosis in patients with metastatic breast cancer | en_US |
dc.type | Article | en_US |
dc.wos.quartile | Q4 (Oncology) | |
dspace.entity.type | Publication | |
local.contributor.department | Tıp Fakültesi/Tıbbi Onkoloji Ana Bilim Dalı | tr_TR |
local.contributor.department | Tıp Fakültesi/Patoloji Ana Bilim Dalı | tr_TR |
local.contributor.department | Tıp Fakültesi/İç Hastalıkları Ana Bilim Dalı | tr_TR |
local.contributor.department | Tıp Fakültesi/Tıbbi Genetik Ana Bilim Dalı | tr_TR |
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