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The GCR2 gene is required for the transcriptional activation of retrotransposon Ty2-917 in Saccharomyces cerevisiae

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dc.contributor.buuauthorTürkel, Sezai
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentBiyoloji Bölümü
dc.contributor.researcheridAAH-6281-2021
dc.contributor.scopusid7003319075
dc.date.accessioned2022-01-21T05:34:23Z
dc.date.available2022-01-21T05:34:23Z
dc.date.issued2002-09
dc.description.abstractTy2 retrotransposons are the mobile genetic elements of the yeast Saccharomyces cerevisiae. Transcriptional regulation of Ty2-917 requires a complex set of cis acting elements which are located both upstream and downstream of the transcription initiation site. Previously, the glycolysis regulatory protein Gcr1p has been identified as the major transcriptional regulator of Ty2-917. Gcr1p is a DNA binding transcription factor that requires Gcr2p for its functions. In this study, the effect of Gcr2p on the transcriptional regulation of Ty2-917 was analyzed. The result of this study indicates that Ty2-917 transcription decreases 24-fold in gcr2 mutant yeast cells. In addition, Ty2 enhancer element dependent transcriptional activation of a heterolog promoter also decreases at a significant level. These results showed that Gcr2p is essential for the high level transcription of Ty2-917.
dc.identifier.citationTürkel, S. (2002). "The GCR2 gene is required for the transcriptional activation of retrotransposon Ty2-917 in Saccharomyces cerevisiae". Biological & Pharmaceutical Bulletin, 25(9),1212-1213.
dc.identifier.doi10.1248/bpb.25.1212
dc.identifier.endpage9
dc.identifier.issn0918-6158
dc.identifier.issue9
dc.identifier.pubmed12230120
dc.identifier.scopus2-s2.0-0036728024
dc.identifier.startpage25
dc.identifier.urihttps://doi.org/10.1248/bpb.25.1212
dc.identifier.urihttps://www.jstage.jst.go.jp/article/bpb/25/9/25_9_1212/_article
dc.identifier.urihttp://hdl.handle.net/11452/24199
dc.identifier.volume25
dc.identifier.wos000177748000021
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherPharmaceutical Society of Japan
dc.relation.journalBiological & Pharmaceutical Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGCR2
dc.subjectRetrotransposon
dc.subjectSaccharomyces cerevisiae
dc.subjectTranscription
dc.subjectTy2
dc.subjectYeast
dc.subjectTransposition
dc.subjectExpression
dc.subjectComplex
dc.subjectElement
dc.subjectSites
dc.subjectPromoter
dc.subject.emtreeArticle
dc.subject.emtreeControlled study
dc.subject.emtreeGCR2 protein, S cerevisiae
dc.subject.emtreeSaccharomyces cerevisiae protein
dc.subject.emtreeTransactivator protein
dc.subject.emtreeDNA binding
dc.subject.emtreeDown regulation
dc.subject.emtreeGcrt2 gene
dc.subject.emtreeSaccharomyces cerevisiae
dc.subject.emtreeGene
dc.subject.emtreeGene activation
dc.subject.emtreeGene identification
dc.subject.emtreeGenetic transcription
dc.subject.emtreeNonhuman; retroposon
dc.subject.emtreeSaccharomyces cerevisiae
dc.subject.emtreeUpregulation
dc.subject.emtreeGenetics
dc.subject.emtreeMetabolism
dc.subject.emtreePhysiology
dc.subject.emtreeTransactivation
dc.subject.emtreeDNA
dc.subject.meshRetroelements
dc.subject.meshSaccharomyces cerevisiae
dc.subject.meshSaccharomyces cerevisiae proteins
dc.subject.meshTrans-activation (Genetics)
dc.subject.meshTrans-activators
dc.subject.scopusRetroelements; Integrases; Gag Protein
dc.subject.wosPharmacology & pharmacy
dc.titleThe GCR2 gene is required for the transcriptional activation of retrotransposon Ty2-917 in Saccharomyces cerevisiae
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentFen Edebiyat Fakültesi/Biyoloji Bölümü
local.indexed.atScopus
local.indexed.atWOS

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