Publication: Recommendations for hepatitis B immunoglobulin and antiviral prophylaxis against hepatitis B recurrence after liver transplantation
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Date
2021-08-31
Authors
Authors
Akarsu, Mesut
Önem, Soner
Turan, İlker
Adalı, Gupse
Akdoğan, Meral
Akyıldız, Murat
Aladağ, Murat
Balaban, Yasemin
Danış, Nilay
Dayangaç, Murat
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Abstract
The combination of hepatitis B immunoglobulin and potent nucleos(t)ide analogs after liver transplantation is considered as the standard of care for prophylaxis against hepatitis B virus recurrence. However, the recommended doses, route of administration, and duration of HBIG administration remain unclear. Moreover, hepatitis B immunoglobulin-free prophylaxis with potent nucleos(t)ide analogs has shown promising disease outcomes in preventing hepatitis B virus recurrence. The current recommendations, produced by the Turkish Association for the Study of the Liver, Acute Liver Failure and Liver Transplantation Special Interest Group, suggest a reduced need for hepatitis B immunoglobulin administration with effective long-term suppression of hepatitis B virus replication using potent nucleos(t)ide analogs after liver transplantation.
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Keywords
Virus recurrence, Immune globulin, Surface-antigen, Nucleos(T)ide analogs, Viral-hepatitis, Prevention, Management, Lamivudine, Efficacy, Outcomes, Hepatitis B, Liver transplantation, Recurrence, Gastroenterology & hepatology
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