Publication:
Evaluation of the anti-endotoxic effects of polymyxin-E (colistin) in dogs with naturally occurred endotoxic shock

dc.contributor.buuauthorŞentürk, Sezgin
dc.contributor.departmentVeteriner Fakültesi
dc.contributor.scopusid56257771200
dc.date.accessioned2021-08-23T10:40:24Z
dc.date.available2021-08-23T10:40:24Z
dc.date.issued2005-02
dc.description.abstractEndotoxin is a potent stimulator of the inflammatory response and is believed to initiate the pathology in gram-negative sepsis. Agents are being searched for that bind and neutralize or block the effects of endotoxin. The aim was to study the anti-endotoxic effects of polymyxin-E (colistin) in endotoxaemic dogs. The study included a total of 30 endotoxaemic dogs, which were divided into two groups (control = 15; test = 15) of both sexes, different breeds and ages. Hetastarch colloid solution (Expahes(R),10 mL/kg, i.v.) with lactated Ringer's solution (20 mL/kg, i.v., Q12 h) was given to all dogs. While ampicillin was administered (Alfasilin(R), 10 mg/kg, i.m., Q12 h) as an antibacterial to the control group, colistin (12 500 IU/kg, i.m., Q12 h) + ampicillin were administered to the test group. The clinical examination (body temperature, pulse and respiration rates, capillary filling times, peripheral pulse qualities, dehydration degrees), hematological and biochemical examinations (WBC, RBC, HGB, HCT, thrombocyte, serum urea, creatinine and TNF-alpha) were performed both before the treatment, and 2, 4, 12 and 24 h after the treatment. In comparison with the control group, it was observed that test group had shorter capillary filling time at 24 h (P < 0.001). Moreover, the degree of dehydration in test group, was significantly improved at 24 h (P < 0.01). While the differences in peripheral pulse qualities significantly differed between 0 and 2 h in controls, at 2, 4, 24 h after treatment it was found to be significantly increased when compared with 0 h in the test group. Serum TNF-alpha concentrations were statistically decreased in the test group between 0 h and other times (P < 0.01). When compared with controls, serum TNF-alpha concentrations were lower at 2, 4, 12 and 24 h in test group (P < 0.05). Results of the study indicated that polymyxin-E (colistin) has an anti-endotoxic effect and is safe for the dogs with endotoxemia at the dosage used in this study.
dc.identifier.citationŞenturk, S. vd. (2005). "Evaluation of the anti-endotoxic effects of polymyxin-E (colistin) in dogs with naturally occurred endotoxic shock". Journal of Veterinary Pharmacology and Therapeutics, 28(1), 57-63.
dc.identifier.endpage63
dc.identifier.issn0140-7783
dc.identifier.issue1
dc.identifier.pubmed15720516
dc.identifier.scopus2-s2.0-14844347960
dc.identifier.startpage57
dc.identifier.urihttps://doi.org/10.1111/j.1365-2885.2004.00634.x
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/j.1365-2885.2004.00634.x
dc.identifier.urihttp://hdl.handle.net/11452/21525
dc.identifier.volume28
dc.identifier.wos000227132900008
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherWiley
dc.relation.journalJournal of Veterinary Pharmacology and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTumor-necrosis-factor
dc.subjectSepsis
dc.subjectHypertonic saline solution
dc.subjectB-Sulfate
dc.subjectSeptic shock
dc.subjectCritical need
dc.subjectFactor-alpha
dc.subjectCalves
dc.subjectColloids
dc.subjectNonapeptide
dc.subjectPharmacology & pharmacy
dc.subjectVeterinary sciences
dc.subject.scopusColistin; Polymyxins; Ventilator Associated Pneumonia
dc.subject.wosPharmacology & pharmacy
dc.subject.wosVeterinary sciences
dc.titleEvaluation of the anti-endotoxic effects of polymyxin-E (colistin) in dogs with naturally occurred endotoxic shock
dc.typeArticle
dc.wos.quartileQ1 (Veterinary sciences)
dc.wos.quartileQ3 (Pharmacology & pharmacy)
dspace.entity.typePublication
local.contributor.departmentVeteriner Fakültesi
local.indexed.atPubMed
local.indexed.atWOS

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