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Trans-Pd/Pt(II) saccharinate complexes with a phosphine ligand: Synthesis, cytotoxicity and structure-activity relationship

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dc.contributor.authorAygün, Muhittin
dc.contributor.authorUlukaya, Engin
dc.contributor.buuauthorİçsel, Ceyda
dc.contributor.buuauthorYılmaz, Veysel T.
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentKimya Bölümü
dc.contributor.orcid0000-0002-2849-3332
dc.contributor.orcid0000-0002-2717-2430
dc.contributor.researcheridAAI-3342-2021
dc.contributor.researcheridL-7238-2018
dc.contributor.scopusid55551960400
dc.contributor.scopusid56441123900
dc.date.accessioned2024-02-13T07:56:40Z
dc.date.available2024-02-13T07:56:40Z
dc.date.issued2020-05-01
dc.description.abstractNew trans-[Pd(sac)(2)(PPhMe2)(DMSO)]center dot H2O (Pd) and trans-[Pt(sac)(2)(PPhMe2)(2)]center dot H2O (Pt) complexes (sac = saccharinate and PPhMe 2 = dimethylphenylphosphine) were synthesized and characterized by elemental analysis, IR, NMR, ESI-MS spectral analyses and X-ray diffraction. The complexes were evaluated for their in vitro cytotoxicity against breast (MCF-7), colon (HCT116) and lung (A549) human cancer cell lines. The ATP viability assay displayed that Pd was biologically inactive, but Pt showed significant anticancer potency on MCF-7 cancer cells, similar to cisplatin. The results suggested that Pt targeted DNA, whereas Pd displayed higher binding affinity towards human serum albumin (HSA). Mechanism of action studies of Pt suggested apoptotic cell death due to significant increase in intracellular ROS (reactive oxygen species) levels, mitochondrial damage and formation of DNA double-strand breaks. Finally, this work represents a new example of potent transplatin anticancer complexes.
dc.identifier.citationİçsel, C. vd. (2020). "Trans-Pd/Pt(II) saccharinate complexes with a phosphine ligand: Synthesis, cytotoxicity and structure-activity relationship". Bioorganic and Medicinal Chemistry Letters, 30(9).
dc.identifier.doi10.1016/j.bmcl.2020.127077
dc.identifier.issn0960-894X
dc.identifier.issn1464-3405
dc.identifier.issue9
dc.identifier.pubmed32156495
dc.identifier.scopus2-s2.0-85081271622
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0960894X20301554
dc.identifier.urihttps://hdl.handle.net/11452/39657
dc.identifier.volume30
dc.identifier.wos000522861200027
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherPergamon-Elsevier Science
dc.relation.collaborationYurt içi
dc.relation.journalBioorganic and Medicinal Chemistry Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitak215Z230
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPharmacology & pharmacy
dc.subjectChemistry
dc.subjectTrans-Pd/Pt complexes
dc.subjectSaccharinate
dc.subjectPhosphine
dc.subjectDNA damage
dc.subjectCytotoxicity
dc.subjectAscites-carcinoma eacs
dc.subjectAntiproliferative activity
dc.subjectPlatinum(II) complexe
dc.subjectAnticancer activity
dc.subjectStrand breaks
dc.subjectIn-vitro
dc.subjectPalladium(II)
dc.subjectDNA
dc.subjectCells
dc.subjectTerpyridine
dc.subject.emtreeAntineoplastic agent
dc.subject.emtreeCisplatin
dc.subject.emtreeDimethylphenylphosphine
dc.subject.emtreeHuman serum albumin
dc.subject.emtreePalladium complex
dc.subject.emtreePalladium saccharinate complex
dc.subject.emtreePhosphine derivative
dc.subject.emtreePlatinum complex
dc.subject.emtreePlatinum saccharinate complex
dc.subject.emtreeReactive oxygen metabolite
dc.subject.emtreeUnclassified drug
dc.subject.emtreeAntineoplastic agent
dc.subject.emtreeCoordination compound
dc.subject.emtreeDNA
dc.subject.emtreeOrganometallic compound
dc.subject.emtreePalladium
dc.subject.emtreePlatinum
dc.subject.emtreeReactive oxygen metabolite
dc.subject.emtreeA-549 cell line
dc.subject.emtreeAntineoplastic activity
dc.subject.emtreeApoptosis
dc.subject.emtreeArticle
dc.subject.emtreeBEAS-2B cell line
dc.subject.emtreeBinding affinity
dc.subject.emtreeCell death
dc.subject.emtreeCell viability
dc.subject.emtreeComplex formation
dc.subject.emtreeConcentration response
dc.subject.emtreeControlled study
dc.subject.emtreeDisorders of mitochondrial functions
dc.subject.emtreeDNA damage
dc.subject.emtreeDNA sequence
dc.subject.emtreeDouble stranded DNA break
dc.subject.emtreeDrug cytotoxicity
dc.subject.emtreeDrug DNA binding
dc.subject.emtreeDrug efficacy
dc.subject.emtreeDrug mechanism
dc.subject.emtreeDrug potency
dc.subject.emtreeDrug structure
dc.subject.emtreeDrug synthesis
dc.subject.emtreeGel electrophoresis
dc.subject.emtreeGene targeting
dc.subject.emtreeHCT 116 cell line
dc.subject.emtreeHuman
dc.subject.emtreeHuman cell
dc.subject.emtreeIC50
dc.subject.emtreeIn vitro study
dc.subject.emtreeLipophilicity
dc.subject.emtreeMCF-7 cell line
dc.subject.emtreeOxidative stress
dc.subject.emtreeSpectrofluorometry
dc.subject.emtreeStereochemistry
dc.subject.emtreeStructure activity relation
dc.subject.emtreeCell survival
dc.subject.emtreeChemistry
dc.subject.emtreeDrug effect
dc.subject.emtreeMolecular model
dc.subject.emtreeStructure activity relation
dc.subject.emtreeSynthesis
dc.subject.emtreeTumor cell line
dc.subject.meshAntineoplastic agents
dc.subject.meshApoptosis
dc.subject.meshCell Line
dc.subject.meshTumor
dc.subject.meshCell Survival
dc.subject.meshCoordination complexes
dc.subject.meshDNA
dc.subject.meshHumans
dc.subject.meshModels, molecular
dc.subject.meshOrganometallic compounds
dc.subject.meshPalladium
dc.subject.meshPlatinum
dc.subject.meshReactive oxygen species
dc.subject.meshSerum albumin, human
dc.subject.meshStructure-activity relationship
dc.subject.scopusComplex; Palladium; 2-Phenylpyridine
dc.subject.wosChemistry, medicinal
dc.subject.wosChemistry, organic
dc.titleTrans-Pd/Pt(II) saccharinate complexes with a phosphine ligand: Synthesis, cytotoxicity and structure-activity relationship
dc.typeArticle
dc.wos.quartileQ2 (Chemistry, medicinal)
dc.wos.quartileQ3 (Chemistry, organic)
dc.wos.quartileQ2
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentFen Edebiyat Fakültesi/Kimya Bölümü
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

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