Publication:
Effect of L-dopa therapy on plasma homocysteine levels and, consequently, on carotid ıntima-media thickness in Parkinson's disease patients

dc.contributor.buuauthorErer, Sevda Özbek
dc.contributor.buuauthorZarifoğlu, Mehmet
dc.contributor.buuauthorAkgül, Çağdaş
dc.contributor.buuauthorTopal, Naile Bolca
dc.contributor.buuauthorOcakoğlu, Gökhan
dc.contributor.buuauthorKarlı, Necdet
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentRadyoloji Ana Bilim Dalı
dc.contributor.departmentKardiyoloji Ana Bilim Dalı
dc.contributor.departmentNöroloji Ana Bilim Dalı
dc.contributor.departmentBiyoistatistik Ana Bilim Dalı
dc.contributor.researcheridAAH-5180-2021
dc.contributor.scopusid25635370800
dc.contributor.scopusid6603411305
dc.contributor.scopusid36981157900
dc.contributor.scopusid13806674200
dc.contributor.scopusid15832295800
dc.contributor.scopusid6506587942
dc.date.accessioned2022-09-27T07:11:36Z
dc.date.available2022-09-27T07:11:36Z
dc.date.issued2010
dc.description.abstractObjective: In this study, we investigated hyperhomocysteinemia, as well as carotid intima-media thickness (CIMT) measurements using carotid Doppler ultrasonography, in Parkinson patients on levodopa treatment. Methods: This study was carried out on 23 patients with Parkinson's disease and 21 age-and gender-matched healthy volunteers. Carotid Doppler ultrasonography was performed in order to determine CIMT in all cases. In addition, plasma homocysteine, vitamin B12 and folate levels were measured. Carotid Doppler ultrasonography and homocysteine levels were repeated one year later to evaluate the rate of atherosclerosis progression. Results: Although the population sample was limited, there was an increase in baseline CIMT measurements that occurred in parallel with an increase in baseline homocysteine levels in these patients. At the end of the follow-up period, a bilateral increase in CIMT was observed, which was not correlated to hyperhomocysteinemia. Conclusion: In conclusion, many clinical studies on hyperhomocysteinemia caused by L-dopa therapy in Parkinson patients have been published. However, the relationship between hyperhomocysteinemia and increased risk of vascular disease is still controversial. On the basis of this result, we speculated that hyperhomocysteinemia might lead to an increase in the arterial wall thickness, but its effect on the progression of atherosclerosis is still discussable.
dc.identifier.citationErer, Ö. S. vd. (2010). "Effect of L-dopa therapy on plasma homocysteine levels and, consequently, on carotid ıntima-media thickness in Parkinson's disease patients". Nöropsikiyatri Arşivi, 47(4), 297-301.
dc.identifier.endpage301
dc.identifier.issn1300-0667
dc.identifier.issue4
dc.identifier.scopus2-s2.0-79251586586
dc.identifier.startpage297
dc.identifier.urihttps://doi.org/10.4274/npa.y5532
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/12682318/
dc.identifier.urihttp://hdl.handle.net/11452/28842
dc.identifier.volume47
dc.identifier.wos000285883500006
dc.indexed.scopusScopus
dc.indexed.trdizinTrDizin
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherTürk Nöropsikiyatri Derneği
dc.relation.journalNöropsikiyatri Arşivi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectParkinson's disease
dc.subjectS-adenosylhomocysteine
dc.subjectCarotid artery diseases
dc.subjectAtherosclerosis
dc.subjectCoronary-heart-disease
dc.subjectLevodopa
dc.subjectRisk
dc.subjectHyperhomocysteinaemia
dc.subjectAtherosclerosis
dc.subjectEntacapone
dc.subjectUltrasound
dc.subjectIncrease
dc.subjectMarkers
dc.subjectExtent
dc.subjectNeurosciences & neurology
dc.subjectParkinson hastalığı
dc.subjectS-adenozilhomosistein
dc.subjectKarotid arter hastalıkları
dc.subjectAteroskleroz
dc.subject.emtreeCyanocobalamin
dc.subject.emtreeDOPA decarboxylase inhibitor
dc.subject.emtreeFolic acid
dc.subject.emtreeHomocysteine
dc.subject.emtreeLevodopa
dc.subject.emtreeAdult
dc.subject.emtreeAmino acid blood level
dc.subject.emtreeArterial wall thickness
dc.subject.emtreeArticle
dc.subject.emtreeCarotid artery
dc.subject.emtreeCarotid atherosclerosis
dc.subject.emtreeClinical article
dc.subject.emtreeControlled study
dc.subject.emtreeDisease course
dc.subject.emtreeDoppler echography
dc.subject.emtreeDrug effect
dc.subject.emtreeFemale
dc.subject.emtreeHuman
dc.subject.emtreeHyperhomocysteinemia
dc.subject.emtreeMale
dc.subject.emtreeParkinson disease
dc.subject.emtreeSex difference
dc.subject.emtreeVitamin blood level
dc.subject.scopusHyperhomocysteinemia; Cyanocobalamin; Folic Acid
dc.subject.wosClinical neurology
dc.titleEffect of L-dopa therapy on plasma homocysteine levels and, consequently, on carotid ıntima-media thickness in Parkinson's disease patients
dc.title.alternativeParkinson hastalarında L-dopa tedavisinin, plazma homosistein düzeyleri ve bununla ilişkili karotis intima-media kalınlıkları üzerine olan etkisi
dc.typeArticle
dc.wos.quartileN/A
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Nöroloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Kardiyoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Radyoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Biyoistatistik Ana Bilim Dalı
local.indexed.atTrDizin
local.indexed.atWOS
local.indexed.atScopus

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