Publication:
Evaluation of oxidative stress in primary glomerulonephritis with serum level of ischemia modified albumin (ima)

dc.contributor.authorAçıkgöz, Ebru
dc.contributor.buuauthorORUÇ, AYŞEGÜL
dc.contributor.buuauthorYILDIZ, ABDULMECİT
dc.contributor.buuauthorYıldız, Abdulmecit
dc.contributor.buuauthorGüllülü, Mustafa
dc.contributor.buuauthorGÜLLÜLÜ, MUSTAFA
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentNefroloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-0342-9692
dc.contributor.researcheridAAH-4002-2021
dc.date.accessioned2024-10-31T06:07:52Z
dc.date.available2024-10-31T06:07:52Z
dc.date.issued2018-01-01
dc.description.abstractOBJECTIVE: Oxidative stress (OS) is described as the imbalance of oxidative and anti-oxidative systems towards oxidants and plays a role in the pathogenesis of GN. In many studies, ischemia-modified albumin (IMA) is identified as a sign of OS. However, it has not yet been studied in patients with primary GN in the literature. In the present study, we aimed to determine the role of IMA in the pathogenesis of primary GN.MATERIAL and METHODS: Forty-five primary GN patients were divided into two groups as proliferative GN (PGN) (n=17, 37.8%) and non-proliferative GN (NPGN) (n=28, 62.2%) according to the histopathological findings. IMA was studied by the cobalt binding method. Since serum albumin levels are commonly low in patients with GN, we calculated the adjusted IMA (aIMA) according to serum albumin.RESULTS: There was no significant difference between the two groups regarding IMA compared with controls (n=50). IMA was significantly higher in the PGN group compared with the control and NPGN groups (p=0.009, 0.037; respectively). There was a negative correlation between serum albumin concentration and IMA.CONCLUSION: These results support the role of OS in the pathogenesis of PGN in which inflammatory immune glomerular injury is predominant.
dc.identifier.doi10.5262/tndt.2017.1003.20
dc.identifier.endpage31
dc.identifier.issn1300-7718
dc.identifier.issue1
dc.identifier.startpage26
dc.identifier.urihttps://doi.org/10.5262/tndt.2017.1003.20
dc.identifier.urihttps://hdl.handle.net/11452/47234
dc.identifier.volume27
dc.identifier.wos000425163400003
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherTurk Nefroloji Diyaliz Transplantasyon Dergisi
dc.relation.journalTurkish Nephrology Dialysis And Transplantation Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectType-2 diabetes-mellitus
dc.subjectGlomerular-diseases
dc.subjectFree-radicals
dc.subjectMarker
dc.subjectInjury
dc.subjectMalondialdehyde
dc.subjectHemodialysis
dc.subjectInflammation
dc.subjectNephropathy
dc.subjectMetabolites
dc.subjectGlomerulonephritis
dc.subjectOxidative stress
dc.subjectIschemia-modified albumin (ima)
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectUrology & nephrology
dc.titleEvaluation of oxidative stress in primary glomerulonephritis with serum level of ischemia modified albumin (ima)
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Nefroloji Ana Bilim Dalı
relation.isAuthorOfPublicatione0f20ddb-a439-4c4a-b87e-d468370abf60
relation.isAuthorOfPublication47f5ec68-c479-4f62-9aed-37ba604a689c
relation.isAuthorOfPublication.latestForDiscoverye0f20ddb-a439-4c4a-b87e-d468370abf60

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