Publication:
Impact of baseline prepulse inhibition on nicotine-induced locomotor sensitization in rats

dc.contributor.authorKayır, Hakan
dc.contributor.authorYavuz, Oğuzhan
dc.contributor.authorUzbay, Tayfun I.
dc.contributor.buuauthorGöktalay, Gökhan
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFarmakoloji Ana Bilim Dalı
dc.contributor.researcheridAAH-1448-2021
dc.contributor.scopusid6508023759
dc.date.accessioned2021-12-31T10:43:07Z
dc.date.available2021-12-31T10:43:07Z
dc.date.issued2011-01-01
dc.description.abstractThe rats having high locomotor reactivity to a novel environment (LRNE) are known to be more vulnerable to develop locomotor sensitization, which reflects the initial neuroplastic changes in brain systems related to addictive behaviours. The present study aimed to investigate whether sensorimotor gating level, measured by prepulse inhibition (PPI) of acoustic startle reflex, also reflects vulnerability for nicotine sensitization. A batch of rats was assigned into three groups according to their baseline PPI values. The highest 1/3 and the lowest 1/3 proportions were selected and defined as high-inhibitory (HI) and low-inhibitory (LI) groups. LRNE was measured in the rats, then they were treated with nicotine (1 mg/kg, tartrate salt, subcutaneously) or saline and locomotor activity (LMA) was immediately recorded for 15 min. This procedure was performed daily for 5 successive days. After a 3-day drug-free period, all rats were challenged with nicotine (1 mg/kg) on 9th day and with saline on 12th day. Same sensitization protocol was applied in another batch of rats, except assigning them into the high-responder (HR) and low-responder(LR) groups according to LRNE levels. There was no significant difference between HI and LI rats in LRNE. Although the acute effect of nicotine on LMA was higher in HI rats, a locomotor sensitization developed and expressed only in LI rats. In the following experiments, nicotine stimulated LMA both in HR and LR rats, but induced and expressed locomotor sensitization only in HR rats. The present study shows that acute locomotor stimulant effect and locomotor sensitization developing effects of nicotine are associated with the baseline PPI and LRNE levels. But these two factors are independent from each other.
dc.identifier.citationKayır, H. vd. (2011). "Impact of baseline prepulse inhibition on nicotine-induced locomotor sensitization in rats". Behavioural Brain Research, 216(1), 275-280.
dc.identifier.endpage280
dc.identifier.issn0166-4328
dc.identifier.issue1
dc.identifier.pubmed20708641
dc.identifier.scopus2-s2.0-78149410521
dc.identifier.startpage275
dc.identifier.urihttps://doi.org/10.1016/j.bbr.2010.08.004
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/20708641/
dc.identifier.urihttp://hdl.handle.net/11452/23789
dc.identifier.volume216
dc.identifier.wos000285318500037
dc.indexed.wosSCIE
dc.indexed.wosSSCI
dc.language.isoen
dc.publisherElsevier
dc.relation.collaborationSanayi
dc.relation.collaborationYurt içi
dc.relation.journalBehavioural Brain Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitak1055387
dc.relation.tubitakSBAG-3194
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBehavioral sciences
dc.subjectNeurosciences & neurology
dc.subjectPrepulse inhibition
dc.subjectNicotine
dc.subjectLocomotor sensitization
dc.subjectIndividual vulnerability
dc.subjectLocomotor reactivity to a novel environment
dc.subjectRat(s)
dc.subjectSensorimotor gating deficits
dc.subjectIndividual-differences
dc.subjectBehavioral sensitization
dc.subjectIncentive-sensitization
dc.subjectSensation seeking
dc.subjectNucleus-accumbens
dc.subjectHigh impulsivity
dc.subjectHealthy humans
dc.subjectAnimal-models
dc.subjectNitric-oxide
dc.subject.emtreeNicotine tartrate
dc.subject.emtreeSodium chloride
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeArticle
dc.subject.emtreeControlled study
dc.subject.emtreeLocomotion
dc.subject.emtreeMale
dc.subject.emtreeNonhuman
dc.subject.emtreePrepulse inhibition
dc.subject.emtreePriority journal
dc.subject.emtreeRat
dc.subject.emtreeSensory gating
dc.subject.emtreeStartle reflex
dc.subject.emtreeStimulus response
dc.subject.emtreeTobacco dependence
dc.subject.meshAcoustic stimulation
dc.subject.meshAnalysis of variance
dc.subject.meshAnimals
dc.subject.meshCentral nervous system stimulants
dc.subject.meshInhibition (psychology)
dc.subject.meshMotor activity
dc.subject.meshNicotine
dc.subject.meshRats
dc.subject.meshSensory gating
dc.subject.meshStartle reaction
dc.subject.scopusPrepulse Inhibition; Startle Reflex; Sensory Gating
dc.subject.wosBehavioral sciences
dc.subject.wosNeurosciences
dc.titleImpact of baseline prepulse inhibition on nicotine-induced locomotor sensitization in rats
dc.typeArticle
dc.wos.quartileQ1 (Behavioral sciences)
dc.wos.quartileQ2 (Neurosciences)
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Farmakoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS

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