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Colchicine in renal Medicine: New virtues of an ancient friend

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dc.contributor.authorSolak, Yalçın
dc.contributor.authorSiriopol, Dimitrie
dc.contributor.authorYılmaz, Mahmut İlker
dc.contributor.authorOrtiz, Alberto
dc.contributor.authorCovic, Adrian
dc.contributor.authorKanbay, Mehmet
dc.contributor.buuauthorYıldız, Abdulmecit
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentİç Hastalıkları Ana Bilim Dalı
dc.contributor.departmentNefroloji Ana Bilim Dalı
dc.contributor.scopusid56256977500
dc.date.accessioned2022-11-03T10:39:21Z
dc.date.available2022-11-03T10:39:21Z
dc.date.issued2016-11-18
dc.description.abstractColchicine is a plant-derived alkaloid that disrupts the cell microtubule system and accumulates in neutrophils, inhibiting neutrophil adhesion and recruitment. Colchicine has been used extensively in the prevention and treatment of gouty arthritis attacks, familial Mediterranean fever attacks and resultant AA amyloidosis, and recurrent pericarditis. Colchicine also disrupts the intracellular traffic of additional inflammatory and fibrosis mediators. Renal fibrosis is the final common pathway of chronic renal disease. Colchicine had anti-fibrotic effects in experimental diabetic nephropathy, renal mass reduction, and cyclosporine nephrotoxicity among others and is undergoing clinical trials for non-diabetic metabolic syndrome and diabetic nephropathy. In this review, we summarize the anti-inflammatory and anti-fibrotic properties of colchicine in experimental and clinical studies in renal diseases or other fibrotic disease processes with renal consequences. We also discuss the potential future uses of colchicine in renal medicine and challenges faced with its use in patients with impaired kidney function.
dc.identifier.citationSolak, Y. vd. (2017). ''Colchicine in renal Medicine: New virtues of an ancient friend''. Blood Purification, 43(1-3), 125-135.
dc.identifier.doi10.1159/000454669
dc.identifier.endpage135
dc.identifier.issn0253-5068
dc.identifier.issn1421-9735
dc.identifier.issue1-3
dc.identifier.pubmed27951538
dc.identifier.scopus2-s2.0-85006314284
dc.identifier.startpage125
dc.identifier.urihttps://doi.org/10.1159/000454669
dc.identifier.urihttps://www.karger.com/Article/FullText/454669
dc.identifier.urihttp://hdl.handle.net/11452/29346
dc.identifier.volume43
dc.identifier.wos000395948100017
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherKarger
dc.relation.collaborationYurt içi
dc.relation.collaborationYurt dışı
dc.relation.collaborationSanayi
dc.relation.journalBlood Purification
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHematology
dc.subjectUrology & nephrology
dc.subjectColchicine
dc.subjectFibrosis
dc.subjectInflammation
dc.subjectKidney disease
dc.subjectFamilial mediterranean fever
dc.subjectChronic cyclosporine nephrotoxicity
dc.subjectInflammatory cell infiltration
dc.subjectPrimary systemic amyloidosis
dc.subjectPrimary biliary-cirrhosis
dc.subjectChronic kidney-disease
dc.subjectDiabetic-nephropathy
dc.subjectMolecular-mechanisms
dc.subjectIinduced neuromyopathy
dc.subjectInterstitial fibrosis
dc.subject.emtreeAlpha tubulin
dc.subject.emtreeBeta tubulin
dc.subject.emtreeC type lectin like receptor
dc.subject.emtreeColchicin e
dc.subject.emtreeCollagen type 1
dc.subject.emtreeCryopyrin
dc.subject.emtreeCytochrome P450 3A4
dc.subject.emtreeFibronectin
dc.subject.emtreeInflammasome
dc.subject.emtreeInterleukin 18
dc.subject.emtreeInterleukin 1beta
dc.subject.emtreeLectin
dc.subject.emtreeMmultidrug resistance protein 1
dc.subject.emtreeSmad protein
dc.subject.emtreeTransforming growth factor beta1
dc.subject.emtreeTumor necrosis factor
dc.subject.emtreeUnclassified drug
dc.subject.emtreeAntiinflammatory agent
dc.subject.emtreeColchicine
dc.subject.emtreeCell division
dc.subject.emtreeChronic kidney failure
dc.subject.emtreeDiabetic nephropathy
dc.subject.emtreeDown regulation
dc.subject.emtreeDrug efficacy
dc.subject.emtreeDrug safety
dc.subject.emtreeExtracellular matrix
dc.subject.emtreeHistopathology
dc.subject.emtreeHuman
dc.subject.emtreeImmunomodulation
dc.subject.emtreeKidney amyloidosis
dc.subject.emtreeKidney disease
dc.subject.emtreeKidney fibrosis
dc.subject.emtreeKidney injury
dc.subject.emtreeKidney tumor
dc.subject.emtreeLiver fibrosis
dc.subject.emtreeNephrotoxicity
dc.subject.emtreePeritoneal fibrosis
dc.subject.emtreePriority journal
dc.subject.emtreeProtein phosphorylation
dc.subject.emtreeReview
dc.subject.emtreeSystematic review
dc.subject.emtreeFibrosis
dc.subject.emtreeKidney diseases
dc.subject.emtreePathology
dc.subject.meshAnti-iInflammatory agents
dc.subject.meshColchicine
dc.subject.meshFibrosis
dc.subject.meshHumans
dc.subject.meshKidney diseases
dc.subject.scopusColchicine; Gloriosa Superba; Gout
dc.subject.wosHematology
dc.subject.wosUrology & nephrology
dc.titleColchicine in renal Medicine: New virtues of an ancient friend
dc.typeReview
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/İç Hastalıkları Ana Bilim Dalı/Nefroloji Ana Bilim Dalı
local.indexed.atWOS
local.indexed.atScopus

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