A rare multisystem disorder: dyskeratosis congenita with gastric carcinoma

Abstract

We report a rare case of dyskeratosis congenita with gastric carcinoma in an adult man whose brother had the same disease. Dyskeratosis congenita is an inherited X-linked disorder characterized by nail dystrophy, skin pigmentation, mucosal leukoplakia and increased incidence of malignancy. Squamous skin carcinoma is also often seen in this disorder. Dyskeratosis in conjuction with gastric carcinoma is very infrequently reported in the literature.