Yayın:
The in vivo and in vitro comparative nephrotoxicity of cefazolin and gentamicin

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dc.contributor.authorYılmaz, Orhan
dc.contributor.authorÇabalar, Mehmet
dc.contributor.buuauthorÖzbilgin, Selda
dc.contributor.departmentVeterinerlik Fakültesi
dc.contributor.departmentPatoloji Ana Bilim Dalı
dc.contributor.scopusid57225240619
dc.date.accessioned2021-11-12T12:33:38Z
dc.date.available2021-11-12T12:33:38Z
dc.date.issued1999
dc.description.abstractBiochemical, histopathological and cell culture evaluations compared the nephrotoxicity of cefazolin with that of gentamicin. New Zealand rabbits were dosed with 250 mg cefazolin/animal im twice daily, 3 mg gentamicin/kg im twice daily, or 0.9% NaCl solution for 10 d. The rabbits in drug-treated groups had necrosis of proximal kidney tubules and elevated urinary-gamma glutamyl transferase (uGGT) levels. The results of the histopathological examinations, uGGT analyses and effects in cell culture indicated the nephrotoxicities of both antibiotics were similar.
dc.identifier.citationYılmaz, O. vd. (1999). "The in vivo and in vitro comparative nephrotoxicity of cefazolin and gentamicin". Veterinary and Human Toxicology, 41(4), 222-225.
dc.identifier.endpage225
dc.identifier.issn0145-6296
dc.identifier.issue4
dc.identifier.pubmed10434375
dc.identifier.scopus2-s2.0-0032794441
dc.identifier.startpage222
dc.identifier.urihttp://hdl.handle.net/11452/22636
dc.identifier.volume41
dc.identifier.wos000081641900007
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherComparative Toxicology Lab
dc.relation.collaborationYurt içi
dc.relation.journalVeterinary and Human Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectToxicology
dc.subjectVeterinary sciences
dc.subjectGamma-glutamyl-transferase
dc.subjectCephalosporin
dc.subjectDogs
dc.subjectRats
dc.subjectAnimalia
dc.subjectOryctolagus cuniculus
dc.subject.emtreeCefazolin
dc.subject.emtreeGamma glutamyltransferase
dc.subject.emtreeGentamicin
dc.subject.emtreeSodium chloride
dc.subject.emtreeAnimal cell
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeAnimal tissue
dc.subject.emtreeArticle
dc.subject.emtreeControlled study
dc.subject.emtreeCytopathology
dc.subject.emtreeDrug induced disease
dc.subject.emtreeHistopathology
dc.subject.emtreeIn vitro study
dc.subject.emtreeIn vivo study
dc.subject.emtreeKidney cell culture
dc.subject.emtreeKidney necrosis
dc.subject.emtreeKidney proximal tubule
dc.subject.emtreeNephrotoxicity
dc.subject.emtreeNonhuman
dc.subject.emtreeRabbit
dc.subject.meshAnimals
dc.subject.meshCattle
dc.subject.meshCefazolin
dc.subject.meshCells, cultured
dc.subject.meshCephalosporins
dc.subject.meshGentamicins
dc.subject.meshKidney
dc.subject.meshRabbits
dc.subject.scopusGentamicins; Nephrotoxicity; Aminoglycoside Antibiotic Agent
dc.subject.wosToxicology
dc.subject.wosVeterinary sciences
dc.titleThe in vivo and in vitro comparative nephrotoxicity of cefazolin and gentamicin
dc.typeArticle
dc.wos.quartileQ2 (Veterinary sciences)
dc.wos.quartileQ4 (Toxicology)
dspace.entity.typePublication
local.contributor.departmentVeterinerlik Fakültesi/Patoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS

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