Publication:
Non-alcoholic steatohepatitis with normal aminotransferase values

dc.contributor.authorBıyıklı, Zeynep
dc.contributor.buuauthorUslusoy, Hüseyin Saadettin
dc.contributor.buuauthorNak, Selim Giray
dc.contributor.buuauthorGülten, Macit
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentGastrenteroloji Ana Bilim Dalı
dc.contributor.scopusid8886940400
dc.contributor.scopusid6603336505
dc.contributor.scopusid6603629209
dc.date.accessioned2021-11-26T07:21:42Z
dc.date.available2021-11-26T07:21:42Z
dc.date.issued2009-04-21
dc.description.abstractAIM: To investigate the aspects of liver histology in patients with non-alcoholic steatohepatitis (NASH) who had normal aminotransferase levels. METHODS: Thirty-four patients diagnosed with liver steatosis by ultrasonographic examination participated in the study. We compared all nonalcoholic fatty liver disease and NASH cases, according to aminotransferase level, aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio and presence of metabolic syndrome. RESULTS: Sixteen of 25 patients with high aminotransferase levels were diagnosed with NASH and nine with simple fatty liver according to liver histology. Among the nine patients with normal aminotransferase levels, seven had NASH and two had simple fatty liver. The patients; with normal and high liver enzyme levels had almost the same prevalence of NASH and metabolic syndrome. Liver histology did not reveal any difference according to aminotransferase levels and AST/ALT ratio. CONCLUSION: Aminotransferase levels and AST/ALT ratio do not seem to be reliable predictors for NASH. Despite numerous non-invasive biomarkers, all patients with fatty liver should undergo liver biopsy.
dc.identifier.citationUslusoy, H. S. vd. (2009). "Non-alcoholic steatohepatitis with normal aminotransferase values". World Journal of Gastroenterology, 15(15), 1863 - 1868.
dc.identifier.endpage1868
dc.identifier.issn1007-9327
dc.identifier.issue15
dc.identifier.pubmed19370784
dc.identifier.scopus2-s2.0-67651241059
dc.identifier.startpage1863
dc.identifier.urihttps://doi.org/10.3748/wjg.15.1863
dc.identifier.urihttps://www.wjgnet.com/1007-9327/full/v15/i15/1863.htm
dc.identifier.urihttp://hdl.handle.net/11452/22814
dc.identifier.volume15
dc.identifier.wos000265385600012
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherBaishideng Publishing
dc.relation.bapBAP
dc.relation.collaborationYurt içi
dc.relation.journalWorld Journal of Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNon-alcoholic steatohepatitis
dc.subjectLiver enzymes
dc.subjectLiver histology
dc.subjectFatty liver-disease
dc.subjectInsulin-resistance
dc.subjectMetabolic significance
dc.subjectComplications
dc.subjectAssociation
dc.subjectDefinition
dc.subjectPrevalence
dc.subjectSpectrum
dc.subjectNonobese
dc.subjectAdults
dc.subjectGastroenterology & hepatology
dc.subject.emtreeAlanine aminotransferase
dc.subject.emtreeAminotransferase
dc.subject.emtreeAspartate aminotransferase
dc.subject.emtreeAbdominal pain
dc.subject.emtreeAdult
dc.subject.emtreeAlanine aminotransferase aspartate amino transferase ratio
dc.subject.emtreeAminotransferase blood level
dc.subject.emtreeAnthropometric parameters
dc.subject.emtreeArticle
dc.subject.emtreeChemical parameters
dc.subject.emtreeClinical article
dc.subject.emtreeClinical feature
dc.subject.emtreeControlled study
dc.subject.emtreeDisease marker
dc.subject.emtreeEchography
dc.subject.emtreeFatty liver
dc.subject.emtreeFemale
dc.subject.emtreeHepatomegaly
dc.subject.emtreeHistology
dc.subject.emtreeHuman
dc.subject.emtreeHuman tissue
dc.subject.emtreeLaboratory diagnosis
dc.subject.emtreeLiver biopsy
dc.subject.emtreeMale
dc.subject.emtreeMetabolic syndrome X
dc.subject.emtreeNonalcoholic fatty liver
dc.subject.emtreeNormal value
dc.subject.meshAdult
dc.subject.meshAlanine transaminase
dc.subject.meshAnthropometry
dc.subject.meshAspartate aminotransferases
dc.subject.meshBiopsy
dc.subject.meshFatty liver
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLiver
dc.subject.meshMale
dc.subject.meshMetabolic syndrome x
dc.subject.meshMiddle aged
dc.subject.meshRetrospective studies
dc.subject.scopusFatty Liver; Proton Density (Concentration); Keratin-18
dc.subject.wosGastroenterology & hepatology
dc.titleNon-alcoholic steatohepatitis with normal aminotransferase values
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Gastrenteroloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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