Publication:
In vitro cytotoxic and antiproliferative effects of usnic acid on hormone-dependent breast and prostate cancer cells

Simple item page
dc.contributor.authorEskiler, Gamze Güney
dc.contributor.buuauthorEryılmaz, Işıl Ezgi
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorYurdacan, Beste
dc.contributor.buuauthorÇeçener, Gülşah
dc.contributor.buuauthorTunca, Berrin
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıbbi Biyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-3316-316X
dc.contributor.orcid0000-0001-7904-883X
dc.contributor.orcid0000-0002-1619-6680
dc.contributor.orcid0000-0002-3820-424X
dc.contributor.researcheridGWV-3548-2022
dc.contributor.researcheridAAH-1656-2021
dc.contributor.researcheridAAH-1420-2021
dc.contributor.researcheridABI-6078-2020
dc.contributor.researcheridAAP-9988-2020
dc.contributor.scopusid57189380840
dc.contributor.scopusid55665145000
dc.contributor.scopusid57203621058
dc.contributor.scopusid6508156530
dc.contributor.scopusid6602965754
dc.date.accessioned2023-10-18T12:39:27Z
dc.date.available2023-10-18T12:39:27Z
dc.date.issued2018-10
dc.description.abstractThe aim of the current study was first to investigate cytotoxic activity of usnic acid (UA) on hormone-dependent breast and prostate cancer, and normal cells. Cells were treated with increasing concentrations (25 to 150 mu M) of UA for 48hours and cell viability, quantitative and morphological analysis of cell death, and cell cycle analysis were performed. UA was shown to have selective cytotoxicity on hormone-dependent cancer cells with the IC50 levels of 71.4 and 77.5 mu M for MCF7 and LNCaP cells, respectively. UA induced apoptotic cell death and G0/G1 cell cycle arrest without damaging normal cells. MCF7 cells were more sensitive to UA than LNCaP cells. Our results first revealed that UA is a promising candidate as an alternative agent for hormone-dependent breast and prostate cancers. However, molecular mechanism underlying the UA-mediated cell death in cancer cells should be investigated further.
dc.identifier.citationEryılmaz, I. E. vd. (2018). ''In vitro cytotoxic and antiproliferative effects of usnic acid on hormone-dependent breast and prostate cancer cells''. Journal of Biochemical and Molecular Toxicology, 32(10).
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue10
dc.identifier.pubmed30101414
dc.identifier.scopus2-s2.0-85052431648
dc.identifier.urihttps://doi.org/10.1002/jbt.22208
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/jbt.22208
dc.identifier.urihttp://hdl.handle.net/11452/34431
dc.identifier.volume32
dc.identifier.wos000447551700009
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherWiley
dc.relation.collaborationYurt içi
dc.relation.journalJournal of Biochemical and Molecular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBiochemistry & molecular biology
dc.subjectToxicology
dc.subjectApoptosis
dc.subjectBreast cancer
dc.subjectHormone-dependent cancers
dc.subjectProstate cancer
dc.subjectUsnic acid
dc.subjectAdjuvant tamoxifen
dc.subjectL-methionine
dc.subjectDna-damage
dc.subjectTherapy
dc.subjectReceptors
dc.subjectLncap
dc.subjectMcf-7
dc.subjectMechanisms
dc.subjectApoptosis
dc.subjectCompound
dc.subject.emtreeHormone
dc.subject.emtreeUsnic acid
dc.subject.emtreeAntineoplastic agent
dc.subject.emtreeBenzofuran derivative
dc.subject.emtreeUsnic acid
dc.subject.emtreeAntiproliferative activity
dc.subject.emtreeApoptosis
dc.subject.emtreeArticle
dc.subject.emtreeBreast cancer
dc.subject.emtreeCancer cell
dc.subject.emtreeCell cycle regulation
dc.subject.emtreeCell proliferation
dc.subject.emtreeCell viability
dc.subject.emtreeControlled study
dc.subject.emtreeCytotoxicity
dc.subject.emtreeHuman
dc.subject.emtreeHuman cell
dc.subject.emtreeIC50
dc.subject.emtreeIn vitro study
dc.subject.emtreeLNCaP cell line
dc.subject.emtreeMCF-7 cell line
dc.subject.emtreePercentage of cells in G0/G1 phase
dc.subject.emtreeProstate cancer
dc.subject.emtreeBreast tumor
dc.subject.emtreeCell cycle G0 phase
dc.subject.emtreeCell cycle G1 phase
dc.subject.emtreeCell line
dc.subject.emtreeDrug effect
dc.subject.emtreeFemale
dc.subject.emtreeMale
dc.subject.emtreeNeoplasm
dc.subject.emtreePathology
dc.subject.emtreeProstate tumor
dc.subject.emtreeTumor cell line
dc.subject.meshAntineoplastic agents
dc.subject.meshApoptosis
dc.subject.meshBenzofurans
dc.subject.meshBreast neoplasms
dc.subject.meshCell line
dc.subject.meshCell line, tumor
dc.subject.meshCell proliferation
dc.subject.meshFemale
dc.subject.meshG1 phase
dc.subject.meshHumans
dc.subject.meshInhibitory concentration 50
dc.subject.meshMale
dc.subject.meshNeoplasms, hormone dependent
dc.subject.meshProstatic neoplasms
dc.subject.meshResting phase, cell cycle
dc.subject.scopusUsnic Acid; Extract; Lichen (Disease)
dc.subject.wosBiochemistry & molecular biology
dc.subject.wosToxicology
dc.titleIn vitro cytotoxic and antiproliferative effects of usnic acid on hormone-dependent breast and prostate cancer cells
dc.typeArticle
dc.wos.quartileQ2 (Biochemistry & molecular biology)
dc.wos.quartileQ3 (Toxicology)
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Biyoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

Files

License bundle

Now showing 1 - 1 of 1
Placeholder
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

İndeksli Yayınlar / Indexed Publications