Publication:
The evaluation of central venous catheter-related complications in pediatric acute leukemia patients: Single center experience

dc.contributor.buuauthorEvim, Melike Sezgin
dc.contributor.buuauthorSEZGİN EVİM, MELİKE
dc.contributor.buuauthorYörük, Gülce
dc.contributor.buuauthorParlak, Ayse
dc.contributor.buuauthorYÖRÜK, GÜLCE
dc.contributor.buuauthorPARLAK, AYŞE
dc.contributor.buuauthorGÜLER, SALİH
dc.contributor.buuauthorÇelik, Fatih
dc.contributor.buuauthorÇELİK, FATİH
dc.contributor.buuauthorÇelebi, Solmaz
dc.contributor.buuauthorÇELEBİ, SOLMAZ
dc.contributor.buuauthorHacımustafaoğlu, Mustafa
dc.contributor.buuauthorHACIMUSTAFAOĞLU, MUSTAFA KEMAL
dc.contributor.buuauthorBaytan, Birol
dc.contributor.buuauthorGüneş, Adalet Meral
dc.contributor.buuauthorMERAL GÜNEŞ, ADALET
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentPediatri Ana Bilim Dalı
dc.contributor.orcid0000-0002-1266-4897
dc.contributor.orcid0000-0001-7686-2561
dc.contributor.orcid0000-0002-9375-2855
dc.contributor.orcid0000-0003-4646-660X
dc.contributor.researcheridAAI-3665-2021
dc.contributor.researcheridAAH-6766-2021
dc.date.accessioned2024-10-08T05:29:02Z
dc.date.available2024-10-08T05:29:02Z
dc.date.issued2023-01-01
dc.description.abstractCentral venous catheters (CVCs) are important for maintenance of childhood leukemia treatment but CVCs may develop complications. The aim of this study was to retrospectively evaluate the CVC-related complication rate, complication types, and outcome in children with acute leukemia. Complications developing in 310 CVCs (ports n=250, Hickman catheters n=60) inserted in 262 patients were evaluated. A total of 225,296 catheter days were screened. Median (range) CVC in-dwelling time was 661.5 (1 to 2636) days. In total, 157 complications developed of which 91 (58%) were infectious complications, 35 (22.3%) were vascular, 19 (12.1%) were surgical, and 12 (7.6%) were mechanical. Hickman catheters had a higher complication rate and were more prone to mechanical complications (P<0.01) but there was no difference for other complications. A lower absolute neutrophil count at insertion was observed in children with infectious complications (P<0.01). Seventy-eight of 136 catheters (57.3%) had to be removed prematurely. The overall complication rate was 0.65 per 1000 catheter days. In multivariate analysis, relapse leukemia, Hickman catheter and low absolute neutrophil count increased complication risk by 4.00, 1.97, and 1.92 times, respectively. Five (1.9%) deaths occurred because of catheter complications. Safe use of CVCs can be improved by early detection of complications and an experienced catheter care team.
dc.identifier.doi10.1097/MPH.0000000000002500
dc.identifier.endpageE96
dc.identifier.issn1077-4114
dc.identifier.issue1
dc.identifier.startpageE92
dc.identifier.urihttps://doi.org/10.1097/MPH.0000000000002500
dc.identifier.urihttps://hdl.handle.net/11452/46015
dc.identifier.volume45
dc.identifier.wos000908061000029
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.journalJournal Of Pediatric Hematology Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.subjectBlood-stream infections
dc.subjectPort insertion
dc.subjectRisk-factors
dc.subjectChildren
dc.subjectNeutropenia
dc.subjectPrevention
dc.subjectAccess
dc.subjectTime
dc.subjectCvc
dc.subjectComplications
dc.subjectChildren
dc.subjectLeukemia
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectOncology
dc.subjectHematology
dc.subjectPediatrics
dc.subjectHematology
dc.titleThe evaluation of central venous catheter-related complications in pediatric acute leukemia patients: Single center experience
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Pediatri Ana Bilim Dalı
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