Publication:
Analysis of p53 gene mutations in parapsoriasis

dc.contributor.buuauthorBaşkan, Emel Bülbül
dc.contributor.buuauthorTunca, Berrin
dc.contributor.buuauthorÇeçener, Gülşah
dc.contributor.buuauthorTunalı, S.
dc.contributor.buuauthorEgeli, Ünal
dc.contributor.buuauthorSarıcaoğlu, H.
dc.contributor.buuauthorAdım, Şadıman Balaban
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıbbi Biyoloji Ana Bilim Dalı
dc.contributor.departmentDermatoloji Ana Bilim Dalı
dc.contributor.departmentPatoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-0144-3263
dc.contributor.orcid0000-0001-7904-883X
dc.contributor.orcid0000-0002-1619-6680
dc.contributor.researcheridAAH-1388-2021
dc.contributor.researcheridAAH-1420-2021
dc.contributor.researcheridABI-6078-2020
dc.contributor.scopusid6602518817
dc.contributor.scopusid9280090300
dc.contributor.scopusid49762870600
dc.contributor.scopusid7004191748
dc.contributor.scopusid49762749200
dc.contributor.scopusid6603722836
dc.contributor.scopusid49762661900
dc.date.accessioned2021-08-23T11:19:39Z
dc.date.available2021-08-23T11:19:39Z
dc.date.issued2006
dc.description.abstractThe histological diagnosis of the initial stages of Mycosis Fungoides (MF) have not yet been established by exact morphological criteria.1 The borderline between parapsoriasis and MF is not clear due to non-specific changes in the early stages of MF. The underlying molecular changes which may occur during progression or transition from parapsoriasis and early MF to advanced stages have not yet been clarified either.2 However, abnormalities of cell cycle control genes and well-defined tumour suppressor genes may contribute to the disease pathogenesis and progression. The p53 gene plays an important role in the control of cell death and proliferation, inducing cell cycle arrest and/ or apoptosis in response to various cellular stress, and alterations of the p53 gene are commonly associated with malignant transformation.3 The p53 gene mutations, one of the most common genetic alterations in human cancers, have been described in several types of haemato logic malignancies.4 By contrast, only a few studies have focused on p53 abnormalities in various categories of T-cell lymphomas and to the best of our knowledge, parasoriasis has not been studied so far.5–10 Studies of p53 protein expression in primary cutaneous T-cell lymphoma have shown to be increased in the late stages of the dis ease. This prompted us to investigate the incidence of p53 gene mutations in parapsoriasis and its role in the pathogenesis.
dc.identifier.citationBaşkan, E. B. vd. (2006). ''Analysis of p53 gene mutations in parapsoriasis''. Journal of the European Academy of Dermatology and Venereology, 20(7), 882-883.
dc.identifier.endpage883
dc.identifier.issn0926-9959
dc.identifier.issn1468-3083
dc.identifier.issue7
dc.identifier.pubmed16898923
dc.identifier.scopus2-s2.0-33746307841
dc.identifier.startpage882
dc.identifier.urihttps://doi.org/10.1111/j.1468-3083.2006.01556.x
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/j.1468-3083.2006.01556.x
dc.identifier.urihttp://hdl.handle.net/11452/21527
dc.identifier.volume20
dc.identifier.wos000239152200029
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherWiley
dc.relation.journalJournal of the European Academy of Dermatology and Venereology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDermatology
dc.subjectProtein
dc.subjectDiagnosis
dc.subjectProgression
dc.subjectT-cell lymphoma
dc.subjectEarly mycosis-fungoides
dc.subject.emtreePsoralen
dc.subject.emtreeProtein p53
dc.subject.emtreeHematoxylin
dc.subject.emtreeGenomic DNA
dc.subject.emtreeEosin
dc.subject.emtreeDNA fragment
dc.subject.emtreeCorticosteroid
dc.subject.emtreeAdolescent
dc.subject.emtreeUltraviolet B radiation
dc.subject.emtreeUltraviolet A radiation
dc.subject.emtreeStaining
dc.subject.emtreeSkin biopsy
dc.subject.emtreeSex ratio
dc.subject.emtreeSequence analysis
dc.subject.emtreeSensitivity analysis
dc.subject.emtreePriority journal
dc.subject.emtreePolymerase chain reaction
dc.subject.emtreePoint mutation
dc.subject.emtreePathogenesis
dc.subject.emtreeParapsoriasis
dc.subject.emtreeMutational analysis
dc.subject.emtreeMale
dc.subject.emtreeHuman
dc.subject.emtreeHeteroduplex analysis
dc.subject.emtreeGene mutation
dc.subject.emtreeGene amplification
dc.subject.emtreeFemale
dc.subject.emtreeExon
dc.subject.emtreeDNA isolation
dc.subject.emtreeDNA binding
dc.subject.emtreeControlled study
dc.subject.emtreeClinical article
dc.subject.emtreeAnamnesis
dc.subject.emtreeAged
dc.subject.emtreeAge distribution
dc.subject.emtreeAdult
dc.subject.meshParapsoriasis
dc.subject.meshMutation
dc.subject.meshMiddle aged
dc.subject.meshMale
dc.subject.meshHumans
dc.subject.meshGenes, p53
dc.subject.meshFemale
dc.subject.meshDNA mutational analysis
dc.subject.meshAged
dc.subject.meshAdult
dc.subject.meshAdolescent
dc.subject.scopusCutaneous T-Cell Lymphoma; Mycosis Fungoides; Sezary Syndrome
dc.subject.wosDermatology
dc.titleAnalysis of p53 gene mutations in parapsoriasis
dc.typeLetter
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Dermatoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Tıbbi Biyoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Patoloji Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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