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The effects of azone and capsaicin on the permeation of naproxen through human skin

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dc.contributor.authorDegim, İ. Tuncer
dc.contributor.authorUslu, A.
dc.contributor.authorHadgraft, Jonathan
dc.contributor.authorAtay, T.
dc.contributor.authorCevheroğlu, S.
dc.contributor.buuauthorAkay, Cemal
dc.contributor.departmentTıp Fakültesi
dc.contributor.orcid0000-0002-2306-5451
dc.contributor.researcheridAAA-7011-2021
dc.date.accessioned2021-06-29T10:08:10Z
dc.date.available2021-06-29T10:08:10Z
dc.date.issued1999-03-01
dc.description.abstractThe permeation of naproxen through excised human skin and isolated perfused rabbit ear skin has been determined. It was found that both Atone and capsaicin enhanced the permeation with an enhancement ratio of up to 4-fold. The magnitudes of the effect were similar in human and rabbit skin. The permeation of naproxen from a saturated solution of the drug through skin pre-treated with Atone was similar to that from a commercial preparation (Naprosyn). In the perfused rabbit ear experiments the presence of capsaicin had no effect on the vasodilatation of the blood vessels, inferring that the penetration enhancement was a direct result of capsaicin influencing the barrier function of the skin. Structural similarities between Atone and capsaicin were seen using molecular graphics.
dc.identifier.citationDegim, İ. T. vd. (1999). "The effects of azone and capsaicin on the permeation of naproxen through human skin". International Journal of Pharmaceutics, 179(1), 21-25.
dc.identifier.doi10.1016/S0378-5173(98)00353-6
dc.identifier.endpage25
dc.identifier.issn0378-5173
dc.identifier.issue1
dc.identifier.pubmed10053198
dc.identifier.scopus2-s2.0-0033011269
dc.identifier.startpage21
dc.identifier.urihttps://doi.org/10.1016/S0378-5173(98)00353-6
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0378517398003536
dc.identifier.urihttp://hdl.handle.net/11452/20899
dc.identifier.volume179
dc.identifier.wos000079392100002
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier Science BV
dc.relation.collaborationYurt içi
dc.relation.collaborationYurt dışı
dc.relation.journalInternational Journal of Pharmaceutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAzone
dc.subjectCapsaicin
dc.subjectNaproxen
dc.subjectPenetration enhancers
dc.subjectSkin absorption
dc.subjectPharmacology & pharmacy
dc.subject.wosPharmacology & pharmacy
dc.titleThe effects of azone and capsaicin on the permeation of naproxen through human skin
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi
local.indexed.atWOS
local.indexed.atScopus

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