Aspirin resistance and oxidative stress in patients with coronary artery disease

Abstract

Objective: To examine the relationship between aspirin resistance and oxidative stress in patients with coronary artery disease.

Material and Method: A total of 100 patients (35 females, 65 males) with coronary arteiy disease were enrolled in the study. Platelet function was evaluated by a Multiple Platelet Function Analyzer according to impedance aggregomeby method. Agregation Unite (AU) with a >706 AU*min despite regular aspirin therapy, was defined as Aspirin resistance. and aspirin semiresponders were defined as a 300-706 AU*min. Aspirin-sensitive patients were defined as a <300 AU*min. While serum malondialdehyde (MDA) and vitamin E concentrations were determined by the high-performance liquid chromatography, other oxidant and antioxidant parameters were measured spectrophotornetrically.

Results: Of the patients studied, 7% were aspirin resistant, 15% were aspirin semiresponders and 78% were aspirin sensitive. While serum MDA, protein carbonyls and total sialic acid concentrations were significantly increased, serum antioxidant vitamins (vitamin E and total carotene) and enzymes (paraoxonase, arylesterase and catalase) were significantly decreased in patients with aspirin resistance. We found strong positive correlations (p<0.001) between aspirin resistance and oxidant parameters and weak negative correlations (p<0.05) between aspirin resistance and antioxidant vitamins and enzymes.

Conclusion: Aspirin resistance is related to oxidant and antioxidant parameters in patients with coronary artery disease. However, there is still need for further studies to better elucidate the relationship between aspirin resistance and oxidative stress, which is now known to be a risk factor for cardiovascular events.