Streptozotocin induced type 1 diabetes mellitus on haematology and erythrocyte sodium potassium in mice

Abstract

Streptozotocin (STZ) is a pancreatic beta-cell toxin that induces rapid and irreversible necrosis of beta-cell (Junod et al., 1967) and is widely used in making experimental animal models of Insulin dependent diabetes mellitus (IDDM) (Rakieten et al., 1963; Brodsky and Logothetopoules, 1969; Junod et al., 1969; Repur, 1970). It is reported that the i.v. injection of 25-200 mg/kg STZ to rats was able to produce a dose-dependent hyperglycemia (Junod et al., 1967). The aim of this paper is to investigate the possible relationship between serum glucose level, body weight, haematocrit level, erythrocyte and leukocyte count, haemoglobin level, erythrocyte sodium and potassium level and type 1 diabetes mellitus in mice with 200 mg/kg STZ induced diabetes.