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Determination of phytochemical contents by LC/ QTOF/MS and evaluation of in-vitro biological activities of 2 Peltigera lichens from Bursa

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Tüzün, Burcu S.
Karadağ, Başak T.
Oran, Seyhan
Öztürk, Şule
Yılmaz, Fethiye F.
Fafal, Tuğle
Kivcak, Bijen

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Acad Brasileira De Ciencias

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Lichens are symbiotic associations of algae and fungi. They are edible as food and have been used in traditional medicine for years. It is aimed to screen phytochemically by LC/QTOF/MS and according to the constituents to evaluate the antioxidant, tyrosinase inhibitory, and antibacterial activities. In total 54 of metabolites detected by LC/QTOF/MS were common in both species. According to LC/QTOF/MS scanning results, alkaloids, iridoid glycosides, phenolics, cyanogenetic glycosides, and terpenic structures were detected. DPPH, ABTS, superoxide radical scavenging activities, and metal chelating capacity IC50 values were 84.55, 9.349; 51.27, 9.127; 95.01, 58.65 and 20.57, 70.08 mu g/mL., respectively. The CUPRAC reducing power was determined as 4.69 and 9.57 TEACCUPRAC, respectively. Tyrosinase inhibitor activity were found to be 86.95 and 196.7 mu g/mL. Both lichens did not show antimicrobial effects. As a result of the antioxidant and tyrosinase inhibitor activities it was seen that their activities were significant and further in vivo studies could be carried out on this lichens.

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Antioxidant activity, Antibacterial activity, Tyrosinase inhibitors, Derivatives, Phenolics, Extracts, Melanogenesis, Alkaloids, Mechanism, Memory, Antioxidant, Lc/qtof/ms, Lichen phenolics, Peltigera elisabethae gyeln., Peltigera praetextata (fl & ouml;rke ex sommerf.), Tyrosinase inhibitor, Science & technology - other topics

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