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5′ MLL gene deletion in a case with childhood acute lymphoblastic leukemia

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dc.contributor.buuauthorGülten, Tuna
dc.contributor.buuauthorYakut, Tahsin
dc.contributor.buuauthorGüneş, Adalet Meral
dc.contributor.buuauthorDemirkaya, Metin
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentÇocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.contributor.departmentTıbbi Genetik Ana Bilim Dalı
dc.contributor.scopusid6505944216
dc.contributor.scopusid6602802424
dc.contributor.scopusid24072843300
dc.contributor.scopusid24331130000
dc.date.accessioned2022-03-16T11:43:18Z
dc.date.available2022-03-16T11:43:18Z
dc.date.issued2010-02
dc.description.abstractMyeloid/lymphoid leukemia (MLL) gene rearrangements are high risk cytogenetic characteristics of acute lymphoblastic leukemia (ALL). Translocations of this gene are well defined, and their impact on the patient's prognosis is well known, but deletions of the same region are rare, and little is known about their prognostic significance and the significance of their accompanying translocations. Here we present a case of childhood ALL with a deletion of the 5' region of the MILL gene detected by fluorescence in situ hybridization (FISH) analysis, This result also confirmed the sensitivity and efficiency of FISH analysis.
dc.identifier.citationGülten, T. vd. (2010). "5′ MLL gene deletion in a case with childhood acute lymphoblastic leukemia". Laboratory Medicine, 41(2), 83-86.
dc.identifier.endpage86
dc.identifier.issn0007-5027
dc.identifier.issue2
dc.identifier.scopus2-s2.0-77951949544
dc.identifier.startpage83
dc.identifier.urihttps://doi.org/10.1309/LMC5LW0IMKNG5LCN
dc.identifier.urihttps://academic.oup.com/labmed/article/41/2/83/2504871
dc.identifier.urihttp://hdl.handle.net/11452/25089
dc.identifier.volume41
dc.identifier.wos000273940800003
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherOxford University
dc.relation.journalLaboratory Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMLL gene deletion
dc.subjectAcute Lymphoblastic Leukemia
dc.subjectFISH analysis
dc.subjectHemotological malignancies
dc.subjectRearrangement
dc.subjectTranslocations
dc.subjectIdentification
dc.subjectAbnormalities
dc.subjectAberrations
dc.subjectApoptosis
dc.subject11Q23
dc.subjectProbe
dc.subjectFish
dc.subjectMedical laboratory technology
dc.subject.emtreeAcute lymphocytic leukemia
dc.subject.emtreeArticle
dc.subject.emtreeCase report
dc.subject.emtreeChild
dc.subject.emtreeChildhood leukemia
dc.subject.emtreeCytogenetics
dc.subject.emtreeFluorescence in situ hybridization
dc.subject.emtreeGene deletion
dc.subject.emtreeGene rearrangement
dc.subject.emtreeGene translocation
dc.subject.emtreeHuman
dc.subject.emtreeMale
dc.subject.emtreeMll gene
dc.subject.emtreeOncogene
dc.subject.emtreePreschool child
dc.subject.emtreePrognosis
dc.subject.emtreeSensitivity and specificity
dc.subject.scopusEPZ-5676; Myeloid-Lymphoid Leukemia Protein; Acute Lymphoblastic Leukemia
dc.subject.wosMedical laboratory technology
dc.title5′ MLL gene deletion in a case with childhood acute lymphoblastic leukemia
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Genetik Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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