Publication:
Anaphylaxis in Turkish children: A multi-centre, retrospective, case study

dc.contributor.authorOrhan, Fazıl
dc.contributor.authorBakırtaş, Arzu
dc.contributor.authorYılmaz, Özge
dc.contributor.authorBoz, Ayşen Bingöl
dc.contributor.authorCan, Demet
dc.contributor.authorKuyucu, Semanur
dc.contributor.authorHarmancı, Koray
dc.contributor.authorTahan, Fulya
dc.contributor.authorReisli, İsmail
dc.contributor.authorKarakaş, Taner
dc.contributor.authorBaki, Ali Erdem
dc.contributor.authorÇokuğraş, Haluk
dc.contributor.authorÇakır, Murat
dc.contributor.buuauthorCanıtez, Yakup
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentPediatrik Alerji ve İmmünoloji Ana Bilim Dalı
dc.contributor.scopusid8988954700
dc.date.accessioned2022-11-08T13:41:14Z
dc.date.available2022-11-08T13:41:14Z
dc.date.issued2011-12
dc.description.abstractBackground Anaphylaxis is a serious and potentially lethal systemic reaction affecting more than one organ or system. Objective We aimed to describe the demographic characteristics, clinical features, causes, settings, and administered therapy in Turkish children. Methods This retrospective, case note study included all children referred to the outpatient clinics of the Pediatric Allergy Departments of the participating study centres from 1 July 1999 to 30 June 2009 for investigation of anaphylaxis or who were seen by us at the moment of the reaction during the same period and who met the clinical criteria of anaphylaxis. Results Two hundred and twenty-four cases of anaphylaxis were reported in 137 children (88 boys, P = 0.0001). The mean +/- SD age at the referral was 7.7 +/- 4.2 years (range: 4 months-17 years). Ninety-eight episodes (43.8%) occurred at home. The symptoms were cutaneous in 222 (99.1%) episodes, respiratory in 217 (96.9%), neuro-psychiatric in 118 (52.7%), cardiovascular in 92 (41.1%), and gastrointestinal in 88 (39.3%). Biphasic reaction was reported in seven episodes (3.1%, 95% CI: 1.5-6.3). Death occurred in one case (0.4%, 95% CI: 0.08-2.4). Treatment was available in 158 episodes (70.5%). Of them, 148 (93.7%) received antihistamines, 132 (83.5%) corticosteroids, 51 (32.3%) epinephrine, and 17 (10.8%) beta-2-mimetics. The causative agents were foods in 86 (38.4%) episodes, hymenoptera venom in 84 (37.5%), drugs and medications in 47 (21.0%), and latex in 5 (2.2%). In two episodes (0.9%), the causative agent was unidentified. Allergy to the trigger was known prior to anaphylaxis in 116 (51.8%) episodes. An epinephrine autoinjector had been prescribed for 70 children (51.1%). Conclusions and Clinical Relevance Anaphylaxis was seen significantly more in boys. Most of the reactions occurred at home. Foods were the most frequent cause. Epinephrine, the first-line treatment of anaphylaxis, was administered in only a third of the children.
dc.identifier.citationOrhan, F. vd. (2011). "Anaphylaxis in Turkish children: A multi-centre, retrospective, case study". Clinical and Experimental Allergy, 41(12), 1767-1776.
dc.identifier.endpage1776
dc.identifier.issn0954-7894
dc.identifier.issn1365-2222
dc.identifier.issue12
dc.identifier.pubmed22092675
dc.identifier.scopus2-s2.0-82155167855
dc.identifier.startpage1767
dc.identifier.urihttps://doi.org/10.1111/j.1365-2222.2011.03859.x
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/22092675/
dc.identifier.urihttp://hdl.handle.net/11452/29432
dc.identifier.volume41
dc.identifier.wos000297283800013
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherWiley
dc.relation.collaborationYurt içi
dc.relation.collaborationSanayi
dc.relation.journalClinical and Experimental Allergy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAllergy
dc.subjectImmunology
dc.subjectAnaphylaxis
dc.subjectChildren
dc.subjectEpidemiology
dc.subjectEmergency-department
dc.subjectAllergic reactions
dc.subjectClinical-features
dc.subjectEpidemiology
dc.subjectSchool children
dc.subjectImmunotherapy
dc.subjectPrevalence
dc.subjectAdrenaline
dc.subjectSeverity
dc.subjectEtiology
dc.subject.emtreeAdrenalin
dc.subject.emtreeAntihistaminic agent
dc.subject.emtreeCorticosteroid
dc.subject.emtreeHymenoptera venom
dc.subject.emtreeLatex
dc.subject.emtreeAdolescent
dc.subject.emtreeAllergy
dc.subject.emtreeAnaphylaxis
dc.subject.emtreeArticle
dc.subject.emtreeBeta adrenergic stimulation
dc.subject.emtreeCardiovascular symptom
dc.subject.emtreeChild
dc.subject.emtreeConfidence interval
dc.subject.emtreeDemography
dc.subject.emtreeFemale
dc.subject.emtreeGastrointestinal symptom
dc.subject.emtreeHuman
dc.subject.emtreeInfant
dc.subject.emtreeMajor clinical study
dc.subject.emtreeMale
dc.subject.emtreeNewborn
dc.subject.emtreePopulation based case control study
dc.subject.emtreePreschool child
dc.subject.emtreePriority journal
dc.subject.emtreeRetrospective study
dc.subject.emtreeSchool child
dc.subject.emtreeTurkey (republic)
dc.subject.meshAdolescent
dc.subject.meshAnaphylaxis
dc.subject.meshChild
dc.subject.meshChild, preschool
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshMale
dc.subject.meshRecurrence
dc.subject.meshRetrospective studies
dc.subject.meshTurkey
dc.subject.scopusFood Allergies; Anaphylaxis; Hypersensitivity
dc.subject.wosAllergy
dc.subject.wosImmunology
dc.titleAnaphylaxis in Turkish children: A multi-centre, retrospective, case study
dc.typeArticle
dc.wos.quartileQ1
dc.wos.quartileQ1
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Pediatrik Alerji ve İmmünoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

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