Publication:
Changes of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure

dc.contributor.authorRubio, Camila Peres
dc.contributor.authorTanaka, Ryou
dc.contributor.authorKoch, Jorgen
dc.contributor.authorCeron, Jose Joaquin
dc.contributor.buuauthorSarıl, Ahmet
dc.contributor.buuauthorKocatürk, Meriç
dc.contributor.buuauthorYılmaz, Zeki
dc.contributor.departmentVeteriner Fakültesi
dc.contributor.departmentDahiliye Ana Bilim Dalı
dc.contributor.orcid0000-0002-2849-1222
dc.contributor.researcheridDQX-5263-2022
dc.contributor.researcheridGGO-7900-2022
dc.contributor.scopusid57202390224
dc.contributor.scopusid36437200800
dc.contributor.scopusid35944810500
dc.date.accessioned2023-01-23T09:33:58Z
dc.date.available2023-01-23T09:33:58Z
dc.date.issued2020-11-10
dc.description.abstractBackgroundHeart failure (HF) is associated with changes in inflammatory and oxidative stress biomarkers. This study aimed to evaluate the changes of a panel of inflammatory and oxidative stress biomarkers in dogs with different stages of HF and its relation with the severity of the disease and echocardiographic changes. A total of 29 dogs with HF as a result of myxomatous mitral valve degeneration or dilated cardiomyopathy were included and classified as stage-A (healthy), B (asymptomatic dogs), C (symptomatic dogs) and D (dogs with end-stage HF) according to the ACVIM staging system. In these dogs an ecnhocardiographic examination was performed and cytokines, and inflammatory and oxidative stress markers were evaluated in serum.ResultsKC-like was significantly increased in dogs of stage-C (P<0.01) and -D (P<0.05) compared with stage-A and -B. Stage-D dogs showed significantly higher serum CRP and Hp (P<0.05) but lower serum antioxidant capacity (PON1, TEAC, CUPRAC, and thiol) compared to stage-A and -B (P<0.05). After the treatment, serum levels of CRP, Hp and KC-like decreased and serum antioxidant levels increased compared to their pre-treatment values. Left ventricular dimension and LA/Ao ratio correlated positively with CRP, MCP-1, and KC-like but negatively with PON1, GM-CSF, IL-7 and antioxidant biomarkers (P<0.01).ConclusionOur results showed that dogs with advanced HF show increases in positive acute-phase proteins and selected inflammatory cytokines such as KC-like, and decreases in antioxidant biomarkers, indicating that inflammation and oxidative stress act as collaborative partners in the pathogenesis of HF. Some of these biomarkers of inflammation and oxidative stress could have the potential to be biomarkers to monitor the severity of the disease and the effect of treatment.
dc.identifier.citationRubio, C. P. vd. (2020). "Changes of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure". BMC Veterinary Research, 16(1).
dc.identifier.issn1746-6148
dc.identifier.issue1
dc.identifier.pubmed33167963
dc.identifier.scopus2-s2.0-85095703346
dc.identifier.urihttps://doi.org/10.1186/s12917-020-02650-7
dc.identifier.urihttps://bmcvetres.biomedcentral.com/articles/10.1186/s12917-020-02650-7
dc.identifier.urihttp://hdl.handle.net/11452/30600
dc.identifier.volume16
dc.identifier.wos000590713300004
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherBMC
dc.relation.bapOUAP(V)-2018/12
dc.relation.collaborationYurt dışı
dc.relation.journalBMC Veterinary Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectVeterinary sciences
dc.subjectCytokines
dc.subjectChemokines
dc.subjectInflammation
dc.subjectOxidative stress
dc.subjectHeart failure
dc.subjectDogs
dc.subjectMitral-valve disease
dc.subjectTotal antioxidant capacity
dc.subjectProtein concentrations
dc.subjectSystemic inflammation
dc.subjectParaoxonase 1
dc.subjectLeft atrial
dc.subjectSerum
dc.subjectCytokines
dc.subjectMarkers
dc.subjectVolume
dc.subject.emtreeAntioxidant
dc.subject.emtreeAryldialkylphosphatase 1
dc.subject.emtreeBilirubin
dc.subject.emtreeBiological marker
dc.subject.emtreeC reactive protein
dc.subject.emtreeCholinesterase
dc.subject.emtreeDigoxin
dc.subject.emtreeDiltiazem
dc.subject.emtreeEnalapril
dc.subject.emtreeFerritin
dc.subject.emtreeFurosemide
dc.subject.emtreeGamma interferon
dc.subject.emtreeGamma interferon inducible protein 10
dc.subject.emtreeGranulocyte macrophage colony stimulating factor
dc.subject.emtreeHaptoglobin
dc.subject.emtreeInterleukin 10
dc.subject.emtreeInterleukin 15
dc.subject.emtreeInterleukin 18
dc.subject.emtreeInterleukin 2
dc.subject.emtreeInterleukin 6
dc.subject.emtreeInterleukin 7
dc.subject.emtreeInterleukin 8
dc.subject.emtreeKeratinocyte derived chemokine
dc.subject.emtreeMonocyte chemotactic protein 1
dc.subject.emtreePimobendan
dc.subject.emtreeSpironolactone
dc.subject.emtreeThiazide diuretic agent
dc.subject.emtreeTorasemide
dc.subject.emtreeTroponin I
dc.subject.emtreeTumor necrosis factor
dc.subject.emtreeAntioxidant
dc.subject.emtreeBiological marker
dc.subject.emtreeCytokine
dc.subject.emtreeABTS radical scavenging assay
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAntioxidant assay
dc.subject.emtreeArticle
dc.subject.emtreeCongestive cardiomyopathy
dc.subject.emtreeControlled study
dc.subject.emtreeCorrelation analysis
dc.subject.emtreeDog
dc.subject.emtreeEchocardiography
dc.subject.emtreeFemale
dc.subject.emtreeHeart failure
dc.subject.emtreeHeart ventricle remodeling
dc.subject.emtreeImmunoturbidimetry
dc.subject.emtreeInflammation
dc.subject.emtreeMale
dc.subject.emtreeNonhuman
dc.subject.emtreeOxidative stress
dc.subject.emtreeThorax radiography
dc.subject.emtreeTrolox equivalent antioxidant capacity
dc.subject.emtreeUrea nitrogen blood level
dc.subject.emtreeAnimal
dc.subject.emtreeBlood
dc.subject.emtreeCardiomyopathy
dc.subject.emtreeDog
dc.subject.emtreeDog disease
dc.subject.emtreeHeart failure
dc.subject.emtreeInflammation
dc.subject.emtreeMitral valve
dc.subject.emtreePathology
dc.subject.emtreeValvular heart disease
dc.subject.emtreeVeterinary medicine
dc.subject.meshAnimals
dc.subject.meshAntioxidants
dc.subject.meshBiomarkers
dc.subject.meshCardiomyopathies
dc.subject.meshCytokines
dc.subject.meshDog diseases
dc.subject.meshDogs
dc.subject.meshEchocardiography
dc.subject.meshFemale
dc.subject.meshHeart failure
dc.subject.meshHeart valve diseases
dc.subject.meshInflammation
dc.subject.meshMale
dc.subject.meshMitral valve
dc.subject.meshOxidative stress
dc.subject.scopusPimobendan; Mitral Valve Disease; Cavalier King Charles Spaniel
dc.subject.wosVeterinary sciences
dc.titleChanges of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure
dc.typeArticle
dc.wos.quartileQ1
dc.wos.quartileQ1
dspace.entity.typePublication
local.contributor.departmentVeteriner Fakültesi/Dahiliye Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

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