Publication: Multicenter evaluation of ceftazidime-avibactam use in carbapenem-resistant klebsiella pneumoniae bloodstream infections in oxa-48 endemic regions
dc.contributor.author | Mert, Ali | |
dc.contributor.author | Derin, Okan | |
dc.contributor.author | Dumlu, Ridvan | |
dc.contributor.author | Gündeş, Sibel | |
dc.contributor.author | Zengin, Rehile | |
dc.contributor.author | Kocagöz, Sesin | |
dc.contributor.author | Gundoğdu, Yasemin | |
dc.contributor.author | Köksal, Iftihar | |
dc.contributor.author | Yalçın, Demet | |
dc.contributor.author | Üstün, Cemal | |
dc.contributor.author | Kapmaz, Mahir | |
dc.contributor.author | Görenek, Levent | |
dc.contributor.author | Karahangil, Kadriye | |
dc.contributor.author | Can, Füsun | |
dc.contributor.author | Ergönül, Önder | |
dc.contributor.buuauthor | AKALIN, EMİN HALİS | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı. | |
dc.contributor.researcherid | KWG-0138-2024 | |
dc.date.accessioned | 2025-02-18T05:53:58Z | |
dc.date.available | 2025-02-18T05:53:58Z | |
dc.date.issued | 2024-11-01 | |
dc.description.abstract | Data in the literature on the use of ceftazidime-avibactam (CAZ-AVI) in carbapenem-resistant Klebsiella pneumoniae bloodstream infections (CRKP-BSIs) are limited especially in OXA-48 (Oxacillinase-48) predominant regions. Our study aimed to evaluate the effect of CAZ-AVI use on outcomes in CRKP-BSIs in Turkey, where OXA-48 is endemic. A multicenter retrospective observational study was conducted between January 2017 and September 2021. The effects of clinical and treatment characteristics on 30-day mortality and relapse in CRKP-BSIs were analyzed. Predictors of outcomes were detected using a Cox regression model. The study enrolled 106 adults with CAZ-AVI-sensitive CRKP-BSIs who received CAZ-AVI for at least 72 h. Patients who received CAZ-AVI as initial therapy had lower mortality rates when compared to those who switched from last resort regimens [14.3% (n = 3/21) vs. 37.7% (n = 32/85), p = 0.04]. In multivariate analysis, older age and severe neutropenia were detected to be associated with higher mortality, significantly. Initiation of CAZ-AVI on the day of blood culture was obtained, was found to be significantly associated with lower mortality (HR: 0.25, CI: 0.07-0.84, p = 0.025). CAZ-AVI monotherapy is an important treatment option for CRKP-BSIs in OXA-48 endemic areas. Early initiation of CAZ-AVI should be preferred rather than switching from a last-resort regimen as it profoundly improves the survival rates. | |
dc.identifier.doi | 10.1038/s41598-024-77259-z | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.issue | 1 | |
dc.identifier.scopus | 2-s2.0-85208291818 | |
dc.identifier.uri | https://doi.org/10.1038/s41598-024-77259-z | |
dc.identifier.uri | https://hdl.handle.net/11452/50491 | |
dc.identifier.volume | 14 | |
dc.identifier.wos | 001346703300034 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Nature Portfolio | |
dc.relation.journal | Scientific Reports | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Bloodstream infections | |
dc.subject | Carbapenem-resistant klebsiella pneumoniae | |
dc.subject | Ceftazidime-avibactam | |
dc.subject | Oxa-48 | |
dc.subject | Oxa-48 endemic area | |
dc.subject | Science & technology | |
dc.subject | Multidisciplinary sciences | |
dc.title | Multicenter evaluation of ceftazidime-avibactam use in carbapenem-resistant klebsiella pneumoniae bloodstream infections in oxa-48 endemic regions | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.contributor.department | Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı. | |
local.indexed.at | WOS | |
local.indexed.at | Scopus | |
relation.isAuthorOfPublication | 4fb46529-3295-4383-97b1-7c494ff32c24 | |
relation.isAuthorOfPublication.latestForDiscovery | 4fb46529-3295-4383-97b1-7c494ff32c24 |
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