Publication:
Development of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effect

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dc.contributor.authorBuz, Pelin Turhan
dc.contributor.authorDuman, Fatma Demir
dc.contributor.authorErkisa, Merve
dc.contributor.authorDemirci, Gözde
dc.contributor.authorUlukaya, Engin
dc.contributor.authorAcar, Havva Yağcı
dc.contributor.buuauthorArı, Ferda
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentBiyoloji
dc.contributor.departmentMoleküler Biyoloji Bölümü
dc.contributor.orcid0000-0002-6729-7908
dc.contributor.researcheridAAG-7012-2021
dc.contributor.scopusid24376085300
dc.date.accessioned2024-02-12T12:40:48Z
dc.date.available2024-02-12T12:40:48Z
dc.date.issued2019-04
dc.description.abstractAim: N-acetyl-L-cysteine (NAC) is a free radical scavenger. We developed NAC-coated Ag2S (NAC-Ag2S) quantum dot (QD) as an optical imaging and therapeutic agent. Materials & methods: QDs were synthesized in water. Their optical imaging potential and toxicity were studied in vitro. Results: NAC-Ag2S QDs have strong emission, that is tunable between 748 and 840 nm, and are stable in biologically relevant media. QDs showed significant differences both in cell internalization and toxicity in vitro. QDs were quite toxic to breast and cervical cancer cells but not to lung derived cells despite the higher uptake. NAC-Ag2S reduces reactive oxygen species (ROS) but causes cell death via DNA damage and apoptosis. Conclusion: NAC-Ag2S QDs are stable and strong signal-generating theranostic agents offering selective therapeutic effects.
dc.description.sponsorshipUludag University (BUAP(F)-2014/3)
dc.identifier.citationBuz, P. T. vd. (2019). ''Development of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effect''. Nanomedicine, 14(8), 969-988.
dc.identifier.endpage988
dc.identifier.issn1743-5889
dc.identifier.issn1748-6963
dc.identifier.issue8
dc.identifier.pubmed30917096
dc.identifier.scopus2-s2.0-85064554881
dc.identifier.startpage969
dc.identifier.urihttps://doi.org/10.2217/nnm-2018-0214
dc.identifier.urihttps://hdl.handle.net/11452/39618
dc.identifier.volume14
dc.identifier.wos000472680000004
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherFuture Medicine
dc.relation.bapBUAP(F)-2014/3
dc.relation.collaborationYurt içi
dc.relation.collaborationSanayi
dc.relation.journalNanomedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitak113Z164
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiotechnology & applied microbiology
dc.subjectScience & technology - other topics
dc.subjectAg2S quantum dots
dc.subjectApoptosis
dc.subjectDNA damage
dc.subjectImaging
dc.subjectN-acetyl-L-cysteine (NAC)
dc.subjectReactive oxygen species (ROS)
dc.subjectDna-damage
dc.subjectHighly luminescent
dc.subjectAcetylcysteine nac
dc.subjectOxidative stress
dc.subjectApoptosis
dc.subjectGlutathione
dc.subjectInduction
dc.subjectToxicity
dc.subjectGrowth
dc.subjectNanoparticles
dc.subject.emtreeAcetylcysteine
dc.subject.emtreeQuantum dot
dc.subject.emtreeReactive oxygen metabolite
dc.subject.emtreeSilver derivative
dc.subject.emtreeSilver sulfide
dc.subject.emtreeWater
dc.subject.emtreeUnclassified drug
dc.subject.emtreeAcetylcysteine
dc.subject.emtreeAntineoplastic agent
dc.subject.emtreeLuminescent agent
dc.subject.emtreeQuantum dot
dc.subject.emtreeReactive oxygen metabolite
dc.subject.emtreeScavenger
dc.subject.emtreeSilver derivative
dc.subject.emtreeSilver sulfide
dc.subject.emtreeApoptosis
dc.subject.emtreeArticle
dc.subject.emtreeBreast cancer cell line
dc.subject.emtreeCell death
dc.subject.emtreeCervical cancer cell line
dc.subject.emtreeControlled study
dc.subject.emtreeDNA damage
dc.subject.emtreeDrug stability
dc.subject.emtreeDrug synthesis
dc.subject.emtreeFluorescence imaging
dc.subject.emtreeIn vitro study
dc.subject.emtreeLung alveolus cell
dc.subject.emtreePhagocytosis
dc.subject.emtreePriority journal
dc.subject.emtreeTherapy effect
dc.subject.emtreeCell survival
dc.subject.emtreeChemistry
dc.subject.emtreeDiagnostic imaging
dc.subject.emtreeDrug effect
dc.subject.emtreeHuman
dc.subject.emtreeInfrared radiation
dc.subject.emtreeLuminescence
dc.subject.emtreeMetabolism
dc.subject.emtreeNeoplasm
dc.subject.emtreeOxidative stress
dc.subject.emtreeParticle size
dc.subject.emtreeSurface property
dc.subject.emtreeTransport at the cellular level
dc.subject.emtreeTumor cell line
dc.subject.meshAcetylcysteine
dc.subject.meshAntineoplastic agents
dc.subject.meshApoptosis
dc.subject.meshBiological transport
dc.subject.meshCell line, tumor
dc.subject.meshCell survival
dc.subject.meshDNA damage
dc.subject.meshFree radical scavengers
dc.subject.meshHumans
dc.subject.meshInfrared rays
dc.subject.meshLuminescence
dc.subject.meshLuminescent agents
dc.subject.meshNeoplasms
dc.subject.meshOxidative stress
dc.subject.meshParticle size
dc.subject.meshQuantum dots
dc.subject.meshReactive oxygen species
dc.subject.meshSilver compounds
dc.subject.meshSurface properties
dc.subject.scopusNanocrystal; Cdte; Forster Resonance Energy Transfer
dc.subject.wosBiotechnology & applied microbiology
dc.subject.wosNanoscience & nanotechnology
dc.titleDevelopment of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effect
dc.typeArticle
dc.wos.quartileQ1 (Biotechnology & applied microbiology)
dc.wos.quartileQ2 (Nanoscience & nanotechnology)
dspace.entity.typePublication
local.contributor.departmentFen Edebiyat Fakültesi/Biyoloji/Moleküler Biyoloji Bölümü
local.indexed.atWOS
local.indexed.atScopus

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