Yayın:
An in vitro study: Inhibitory effect of carfilzomib on human serum paraoxonase-1 (hpon1)

Basit Görünüm
dc.contributor.buuauthorSöyüt, Hakan
dc.contributor.buuauthorSÖYÜT, HAKAN
dc.contributor.departmentEğitim Fakültesi
dc.date.accessioned2024-10-25T10:48:46Z
dc.date.available2024-10-25T10:48:46Z
dc.date.issued2022-01-01
dc.description.abstractBackground and Objective: hPON1 is an HDL-related lactonase that can inhibit LDL. It is considered atheroprotective. hPON1 contributes to the antioxidant function of HDL. It is believed that a decrease in PON1 activity may promote atherosclerosis. This article was aimed to investigate the inhibitory effect of carfilzomib on hPON1. Materials and Methods: In this study, we detect the inhibition between hPON1 and carfilzomib used in the treatment of myeloma. Results: We determined that carfilzomib showed very strong inhibitory properties for human serum PON1, with an IC50 value of 43.31 mu M and a mean K-i value of 44.37 mu M. We determined that carfilzomib showed competitive inhibition. Conclusion: The use of carfilzomib, which has a very strong inhibitory effect, in the treatment of multiple myeloma can be very harmful.
dc.identifier.doi10.3923/ijp.2022.522.526
dc.identifier.endpage526
dc.identifier.issn1811-7775
dc.identifier.issue3
dc.identifier.startpage522
dc.identifier.urihttps://doi.org/10.3923/ijp.2022.522.526
dc.identifier.urihttps://hdl.handle.net/11452/47098
dc.identifier.volume18
dc.identifier.wos000787558900012
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherAsian Network Scientific Information-ansinet
dc.relation.journalInternational Journal Of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOxidative stress
dc.subjectBlood-pressure
dc.subjectPon1
dc.subjectMouse
dc.subjectPurification
dc.subjectExpression
dc.subjectParaoxonase
dc.subjectCarfilzomib
dc.subjectInhibition
dc.subjectAnticancer drug
dc.subjectMultiple myeloma
dc.subjectHdl
dc.subjectLymphoblastic lymphoma
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectPharmacology & pharmacy
dc.titleAn in vitro study: Inhibitory effect of carfilzomib on human serum paraoxonase-1 (hpon1)
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentEğitim Fakültesi
local.indexed.atWOS
relation.isAuthorOfPublication71fcc315-c95c-4f00-898e-183c34d8b375
relation.isAuthorOfPublication.latestForDiscovery71fcc315-c95c-4f00-898e-183c34d8b375

Dosyalar

Koleksiyonlar

İndeksli Yayınlar / Indexed Publications