The relationship between intraoperative body temperature and thiol/disulfide balance in geriatric patients undergoing elective transurethral prostate resection surgery with spinal anesthesia

Abstract

OBJECTIVE: We aimed to investigate the relationship between intraoperative body temperature and thiol/disulfide balance in geriatric patients scheduled for elective transurethral prostate resection surgery with spinal anesthesia.PATIENTS AND METHODS: 71 patients classified as categories 1 and 2, according to American Society of Anesthesiologists (ASA) classification, were included in the study. The core temperature of the patients was recorded in the operating room after monitoring, at 5 and 30 minutes after spinal anesthesia. Total thiols, native thiols, disulfide amounts, disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol were calculated as percentages after monitorization (T-preoperative) and at 60 minutes after spinal anesthesia (T-intraoperative).RESULTS: The disulfide levels in the T-intraoperative period (29 +/- 8.9 mmol/L) were higher than the disulfide levels measured in the T-preoperative period (18.2 +/- 8.8 mmol/L) (p<0.001). In the T-preoperative period, the disulfide/native thiol (%) level was 4.6 +/- 2, while the disulfide/total thiol (%) level was 4.2 +/- 1.6. In the T-intraoperative period, the disulfide/native thiol (%) level was 8 +/- 2.3, while the disulfide/total thiol (%) level was 6.8 +/- 1.7. Native thiol/total thiol (%) levels for the T-preoperative and T-intraoperative periods were 91.5 +/- 3.3 mmol/L and 86.3 +/- 3.4 mmol/L, respectively. A correlation was found between native, total thiol levels and patient age in the T-preoperative and T-intraoperative periods.CONCLUSIONS: Oxidative stress can be reduced in geriatric patients with the possibility of developing involuntary perioperative hypothermia by regularly monitoring body temperature and applying warming techniques.