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Long non-coding rnas as a predictive markers of group 3 medulloblastomas

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dc.contributor.authorMutlu, Melis
dc.contributor.authorTekin, Çağla
dc.contributor.authorAk Aksoy, Seçil
dc.contributor.authorTaşkapılıoğlu, Mevlüt Özgur
dc.contributor.authorKaya, Seçkin
dc.contributor.authorBalcin, Rabia Nur
dc.contributor.authorOcak, Pınar Eser
dc.contributor.authorBekar, Ahmet
dc.contributor.authorTolunay, Şahsine
dc.contributor.authorTunca, Berrin
dc.contributor.buuauthorMutlu, Melis
dc.contributor.buuauthorTekin, Çağla
dc.contributor.buuauthorAk Aksoy, Seçil
dc.contributor.buuauthorTAŞKAPILIOĞLU, MEVLÜT ÖZGÜR
dc.contributor.buuauthorKAYA, İSMAİL SEÇKİN
dc.contributor.buuauthorBALÇIN, RABİA NUR
dc.contributor.buuauthorOCAK, PINAR
dc.contributor.buuauthorBEKAR, AHMET
dc.contributor.buuauthorTOLUNAY, ŞAHSİNE
dc.contributor.buuauthorTUNCA, BERRİN
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/İnegöl Meslek Yüksekokulu.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Beyin Cerrahi Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.
dc.contributor.orcid0000-0001-5472-9065
dc.contributor.orcid0000-0002-4256-2250
dc.contributor.orcid0000-0003-0132-9927
dc.contributor.orcid0000-0002-1619-6680
dc.contributor.researcheridGXV-3107-2022
dc.contributor.researcheridAAI-2073-2021
dc.contributor.researcheridADM-8457-2022
dc.contributor.researcheridABX-9081-2022
dc.contributor.researcheridFPB-0403-2022
dc.contributor.researcheridGDC-6329-2022
dc.contributor.researcheridAAW-5254-2020
dc.contributor.researcheridJGS-1849-2023
dc.contributor.researcheridFDK-3229-2022
dc.contributor.researcheridAAI-1612-2021
dc.date.accessioned2024-06-07T08:24:40Z
dc.date.available2024-06-07T08:24:40Z
dc.date.issued2021-08-28
dc.description.abstractObjective The appropriate treatments for the different molecular subgroups of medulloblastomas are challenging to determine. Hence, this study aimed to examine the expression profiles of long non-coding RNAs (LncRNAs) to determine a marker that may be important for treatment selection in these subgroups. Methods Changes in the expression of LncRNAs in the tissues of patients with medulloblastoma, which are classified into four subgroups according to their clinical characteristics and gene expression profiles, were examined via reverse transcription polymerase chain reaction. Moreover, there association with patient prognosis was evaluated. Results The expression levels of MALAT1 and SNGH16 were significantly higher in patients with group 3 medulloblastoma than in those with other subtypes. Patients with high expression levels of MALAT1 and SNGH16 had a relatively shorter overall survival than those with low expression levels. Conclusions Patients with group 3 medulloblastoma have a high MALAT1 level, which is associated with poor prognosis. Therefore, MALAT1 can be a new therapeutic target in medulloblastoma.
dc.identifier.doi10.1080/01616412.2021.1975223
dc.identifier.eissn1743-1328
dc.identifier.endpage241
dc.identifier.issn0161-6412
dc.identifier.issue3
dc.identifier.startpage232
dc.identifier.urihttps://doi.org/10.1080/01616412.2021.1975223
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/01616412.2021.1975223
dc.identifier.urihttps://hdl.handle.net/11452/41876
dc.identifier.volume44
dc.identifier.wos000696855700001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.bapOUAP(T)-2019/3
dc.relation.journalNeurological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMolecular subgroups
dc.subjectCancer
dc.subjectGene
dc.subjectMir-675
dc.subjectMalat1
dc.subjectExpression
dc.subjectTherapy
dc.subjectMedulloblastoma
dc.subjectSubgroups
dc.subjectLncrna
dc.subjectPrognosis
dc.subjectNeurosciences & neurology
dc.titleLong non-coding rnas as a predictive markers of group 3 medulloblastomas
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublication121a3732-be5d-4aff-9195-357c8347daca
relation.isAuthorOfPublication.latestForDiscovery5366e0c2-f020-4a2d-8d97-46928026680f

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