Publication:
Serological relationships among subgroups in bovine viral diarrhea virus genotype 1 (BVDV-1)

dc.contributor.buuauthorAlpay, Gizem
dc.contributor.buuauthorYeşilbağ, Kadir
dc.contributor.departmentVeterinerlik Fakültesi
dc.contributor.departmentViroloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-3411-081X
dc.contributor.orcid0000-0003-1793-6879
dc.contributor.researcheridAAH-3917-2021
dc.contributor.researcheridABE-7662-2020
dc.contributor.scopusid54079452300
dc.contributor.scopusid6602912127
dc.date.accessioned2022-08-12T12:31:41Z
dc.date.available2022-08-12T12:31:41Z
dc.date.issued2015-01-30
dc.description.abstractBovine viral diarrhea virus (BVDV) has various economic impacts associated with diarrhea, poor performance, an increase in the frequency of other infections and lethal outcomes. Both genotypes, namely BVDV-1 and BVDV-2, as well as different subgroups within these genotypes have been reported worldwide. Understanding the serological differences among the BVDV subgroups is important for disease epidemiology and prevention as well as vaccination programs. The aim of this study was to determine the serological relatedness among the subgroups in BVDV-1. For that purpose, sheep hyperimmune sera were collected against representative strains from 6 of the subgroups of BVDV-1 (BVDV-1a, -1b, -1d, -1f, -1h and -1l). The serum samples that gave the peak antibody titer to the homologous strains were used to perform cross neutralization assays. The highest homologous antibody titer (1:5160) was obtained against BVDV-1h. Regarding the cross neutralizing (heterologous) antibodies, the lowest titer (1:20) was produced by the BVDV-1f antiserum against the BVDV-1a and BVDV1-b viruses. The highest cross neutralizing titer (1:2580) achieved by the BVDV-1h antiserum was against the BVDV-1b strain. The cross neutralization results indicated particular serological differences between the recently described subgroup (BVDV-1l) and BVDV-1a/-1b, which are widely used in commercial vaccines. Considering the cross neutralization titers, it is concluded that selected BVDV-1l and BVDV-1h strains can be used for the development of diagnostic and control tools.
dc.description.sponsorshipUludag University (2010/43)
dc.identifier.citationAlpay, G. ve Yeşilbağ K. (2015). "Serological relationships among subgroups in bovine viral diarrhea virus genotype 1 (BVDV-1)". Veterinary Microbiology, 175(1), 1-6.
dc.identifier.endpage6
dc.identifier.issn0378-1135
dc.identifier.issn1873-2542
dc.identifier.issue1
dc.identifier.pubmed25487441
dc.identifier.scopus2-s2.0-84916214718
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1016/j.vetmic.2014.10.034
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0378113514005124
dc.identifier.urihttp://hdl.handle.net/11452/28188
dc.identifier.volume175
dc.identifier.wos000348083100001
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier
dc.relation.journalVeterinary Microbiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitak109-0-762
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBovine viral diarrhea virus
dc.subjectBVDV-1
dc.subjectCross neutralization
dc.subjectSerological relation
dc.subjectSubgroup
dc.subjectMicrobiology
dc.subjectVeterinary Sciences
dc.subjectAntigenic diversity
dc.subjectFetal protection
dc.subjectInfection
dc.subjectIdentification
dc.subjectHeterogeneity
dc.subjectSubgenotypes
dc.subjectVaccination
dc.subjectExposure
dc.subjectFailure
dc.subjectDisease
dc.subject.emtreeAntiserum
dc.subject.emtreeNeutralizing antibody
dc.subject.emtreeVirus antibody
dc.subject.emtreeVirus antigen
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAntibody titer
dc.subject.emtreeArticle
dc.subject.emtreeBlood sampling
dc.subject.emtreeBovine viral diarrhea virus 1
dc.subject.emtreeBovine viral diarrhea virus 1a
dc.subject.emtreeBovine viral diarrhea virus 1b
dc.subject.emtreeBovine viral diarrhea virus 1d
dc.subject.emtreeBovine viral diarrhea virus 1f
dc.subject.emtreeBovine viral diarrhea virus 1h
dc.subject.emtreeBovine viral diarrhea virus 1l
dc.subject.emtreeControlled study
dc.subject.emtreeExperimental sheep
dc.subject.emtreeGenotype
dc.subject.emtreeImmunization
dc.subject.emtreeNonhuman
dc.subject.emtreeSerology
dc.subject.emtreeVirus neutralization
dc.subject.emtreeVirus strain
dc.subject.emtreeAnimal
dc.subject.emtreeBlood
dc.subject.emtreeBovine
dc.subject.emtreeBovine viral diarrhea
dc.subject.emtreeBovine viral diarrhea virus 1
dc.subject.emtreeCell line
dc.subject.emtreeDiarrhea
dc.subject.emtreeGenetics
dc.subject.emtreeImmunology
dc.subject.emtreeSheep
dc.subject.emtreeSpecies difference
dc.subject.emtreeVirology
dc.subject.meshAnimals
dc.subject.meshAntibodies, neutralizing
dc.subject.meshAntibodies, viral
dc.subject.meshAntigens, viral
dc.subject.meshBovine virus diarrhea-mucosal disease
dc.subject.meshCattle
dc.subject.meshCell line
dc.subject.meshDiarrhea
dc.subject.meshDiarrhea virus 1, bovine viral
dc.subject.meshGenotype
dc.subject.meshSheep
dc.subject.meshSpecies specificity
dc.subject.scopusBovine Viral Diarrhea Viruses; Pestivirus; Cattle
dc.subject.wosMicrobiology
dc.subject.wosVeterinary sciences
dc.titleSerological relationships among subgroups in bovine viral diarrhea virus genotype 1 (BVDV-1)
dc.typeArticle
dc.wos.quartileQ1 (Veterinary sciences)
dc.wos.quartileQ2 (Microbiology)
dc.wos.quartileQ1
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentVeterinerlik Fakültesi/Viroloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

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