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Decreased plasma levels of soluble receptor for advanced glycation endproducts (sRAGE) in patients with nonalcoholic fatty liver disease

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dc.contributor.authorAtuğ, Özlen
dc.contributor.authorYılmaz, Yusuf
dc.contributor.buuauthorUlukaya, Engin
dc.contributor.buuauthorGül, Özen Öz
dc.contributor.buuauthorArabul, Mahmut
dc.contributor.buuauthorGül, Cuma Bülent
dc.contributor.buuauthorOral, Arzu Yılmaztepe
dc.contributor.buuauthorAker, Sibel
dc.contributor.buuauthorDolar, Mahmut Enver
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentBiyokimya Ana Bilim Dalı
dc.contributor.departmentEndokrinoloji Ana Bilim Dalı
dc.contributor.departmentDahiliye Ana Bilim Dalı
dc.contributor.orcid0000-0003-2467-9356
dc.contributor.orcid0000-0003-0463-6818
dc.contributor.orcid0000-0003-4518-5283
dc.contributor.researcheridA-7063-2018
dc.contributor.researcheridAAI-1005-2021
dc.contributor.researcheridAAG-9177-2021
dc.contributor.researcheridA-5841-2017
dc.contributor.researcheridK-5792-2018
dc.contributor.scopusid22936014300
dc.contributor.scopusid6602927353
dc.contributor.scopusid26040787100
dc.contributor.scopusid15925230900
dc.contributor.scopusid23988796000
dc.contributor.scopusid23091316500
dc.contributor.scopusid12795285000
dc.contributor.scopusid6602075084
dc.date.accessioned2021-11-15T08:29:20Z
dc.date.available2021-11-15T08:29:20Z
dc.date.issued2009-06
dc.description.abstractObjectives: Levels of soluble receptor for advanced glycation endproducts (sRAGE) have been linked to several components of the metabolic syndrome. We tested the hypothesis that plasma levels of sRAGE may be associated with non-alcoholic fatty liver disease. Design and methods: We enrolled subjects with definite nonalcoholic steatohepatitis (NASH, n=40), borderline NASH (n=8), simple fatty liver (n=9) and healthy controls (n=14). Plasma levels of sRAGE were measured by ELISA. Results: Concentrations of sRAGE were significantly lower in patients with definite NASH (1080 +/- 392 pg/mL, P<0.01) and borderline NASH (1050 +/- 278 pg/mL, P<0.05) compared to controls (1480 +/- 387 pg/mL). Levels of sRAGE were significantly and inversely correlated with ALT (r=-0.30, P<0.05) and AST (r=-0.23, P<0.05). Conclusion: Plasma levels of sRAGE are significantly reduced in definite and borderline NASH.
dc.identifier.citationYılmaz, Y. vd. (2009). "Decreased plasma levels of soluble receptor for advanced glycation endproducts (sRAGE) in patients with nonalcoholic fatty liver disease". Clinical Biochemistry, 42(9), 802-807.
dc.identifier.endpage807
dc.identifier.issn0009-9120
dc.identifier.issue9
dc.identifier.pubmed19217891
dc.identifier.scopus2-s2.0-67349263467
dc.identifier.startpage802
dc.identifier.urihttps://doi.org/10.1016/j.clinbiochem.2009.02.003
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0009912009000848
dc.identifier.urihttp://hdl.handle.net/11452/22650
dc.identifier.volume42
dc.identifier.wos000266295900008
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherPergamon-Elsevier Science
dc.relation.collaborationYurt içi
dc.relation.journalClinical Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFatty liver
dc.subjectBiological markers
dc.subjectReceptor for advanced glycation endproducts (RAGE)
dc.subjectEnzyme-linked immunosorbent assay
dc.subjectEnd-products ages
dc.subjectInsulin-resistance
dc.subjectSerum-levels
dc.subjectRage
dc.subjectForm
dc.subjectPathogenesis
dc.subjectGalectin-3
dc.subjectProtein
dc.subjectMedical laboratory technology
dc.subject.emtreeAdvanced glycation end product receptor
dc.subject.emtreeAlanine aminotransferase
dc.subject.emtreeAdult
dc.subject.emtreeAlanine aminotransferase blood level
dc.subject.emtreeControlled study
dc.subject.emtreeArticle
dc.subject.emtreeDisease association
dc.subject.emtreeEnzyme linked immunosorbent assay
dc.subject.emtreeFatty liver
dc.subject.emtreeFemale
dc.subject.emtreeHuman
dc.subject.emtreeHuman tissue
dc.subject.emtreeInsulin resistance
dc.subject.emtreeLiver biopsy
dc.subject.emtreeMajor clinical study
dc.subject.emtreeMale
dc.subject.emtreeNonalcoholic fatty liver
dc.subject.emtreePriority journal
dc.subject.emtreeProtein blood level
dc.subject.meshAdult
dc.subject.meshEnzyme-linked immunosorbent assay
dc.subject.meshFatty liver
dc.subject.meshHumans
dc.subject.meshMiddle aged
dc.subject.meshReceptors, immunologic
dc.subject.scopusAdvanced Glycation End Product Receptor; 6 N Carboxymethyllysine; Glycation
dc.subject.wosMedical laboratory technology
dc.titleDecreased plasma levels of soluble receptor for advanced glycation endproducts (sRAGE) in patients with nonalcoholic fatty liver disease
dc.typeArticle
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Biyokimya Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Endokrinoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Dahiliye Ana Bilim Dalı
local.indexed.atScopus
local.indexed.atWOS

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