Publication:
Design and in vivo evaluation of alginate-based pH-sensing electrospun wound dressing containing anthocyanins

dc.contributor.buuauthorPakolpakçıl, Ayben
dc.contributor.buuauthorOsman, Bilgen
dc.contributor.buuauthorGöktalay, Gökhan
dc.contributor.buuauthorÖzer, Elif Tümay
dc.contributor.buuauthorŞahan, Yasemin
dc.contributor.buuauthorBecerir, Behçet
dc.contributor.buuauthorKaraca, Esra
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentZiraat Fakültesi
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentMühendislik Fakültesi
dc.contributor.departmentFarmakoloji Ana Bilim Dalı
dc.contributor.departmentGıda Mühendisliği
dc.contributor.departmentKimya Bölümü
dc.contributor.departmentTekstil Mühendisliği
dc.contributor.orcid0000-0002-6981-4980
dc.contributor.orcid0000-0002-2655-2773
dc.contributor.orcid0000-0003-1777-3977
dc.contributor.orcid0000-0001-6261-4233
dc.contributor.researcheridADX-6657-2022
dc.contributor.researcheridABF-4791-2020
dc.contributor.researcheridAAH-1448-2021
dc.contributor.researcheridJIV-6630-2023
dc.contributor.researcheridIHI-9909-2023
dc.contributor.researcheridAAH-1445-2021
dc.contributor.researcheridAAS-8480-2020
dc.contributor.scopusid57204420713
dc.contributor.scopusid15221651200
dc.contributor.scopusid6508023759
dc.contributor.scopusid37047586000
dc.contributor.scopusid25629856600
dc.contributor.scopusid9839809500
dc.contributor.scopusid17344029200
dc.date.accessioned2024-01-18T08:03:40Z
dc.date.available2024-01-18T08:03:40Z
dc.date.issued2021-02
dc.description.abstractIn this study, a pH-sensing electrospun mat containing purple cabbage (PC) (Brassica oleracea) anthocyanins was developed for wound dressing application. The pH-sensing electrospun mat was prepared from sodium alginate (Alg) and poly (vinyl alcohol) (PVA) via electrospinning. PC anthocyanins were embedded into the electrospun mat with the addition of PC extract into the Alg/PVA electrospun solution. The characterization studies were conducted by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), water contact angle (WCA) and thickness measurements. The halochromic behavior of the pH-sensing Alg/PVA/PC electrospun mat was elucidated via UV-Vis spectrophotometric analyses and color measurements obtained from quantitative color data. In vivo performance of the pH-sensing mat was evaluated by animal studies. The electrospun mat was successfully used to monitor pH changes of an open wound. In addition, wound healing efficacy of the electrospun mat was compared with a commercial wound dressing. The results revealed that a wound dressing benefiting from halochromic properties of the anthocyanins besides wound healing efficacy of Alg was successfully developed. The pH-sensing Alg/PVA/PC electrospun mat has a usage potential for wound dressing applications especially for monitoring wound status on real-time during healing period.
dc.identifier.citationPokalpakçıl, A. vd. (2021). "Design and in vivo evaluation of alginate-based pH-sensing electrospun wound dressing containing anthocyanins". Journal of Polymer Research, 28(2).
dc.identifier.doihttps://doi.org/10.1007/s10965-020-02400-1
dc.identifier.issn1022-9760
dc.identifier.issn1572-8935
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85099412902
dc.identifier.urihttps://link.springer.com/article/10.1007/s10965-020-02400-1
dc.identifier.urihttps://hdl.handle.net/11452/39145
dc.identifier.volume28
dc.identifier.wos000609804000003
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherSpringer
dc.relation.collaborationYurt içi
dc.relation.journalJournal of Polymer Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitak116M540
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectpH sensing
dc.subjectAnthocyanin
dc.subjectNanofiber
dc.subjectElectrospinning
dc.subjectWound dressing
dc.subjectIn vivo
dc.subjectContact angle
dc.subjectFourier transform infrared spectroscopy
dc.subjectPolyvinyl alcohols
dc.subjectScanning electron microscopy
dc.subjectSodium alginate
dc.subjectThickness measurement
dc.subjectTissue regeneration
dc.subjectAnimal studies
dc.subjectBrassica oleracea
dc.subjectCharacterization studies
dc.subjectColor measurements
dc.subjectPoly (vinyl alcohol) (PVA)
dc.subjectSpectrophotometric analysis
dc.subjectWater contact angle (WCA)
dc.subjectWound dressings
dc.subjectpH sensors
dc.subject.scopusBandages; PH Sensors; Wound Healing
dc.subject.wosPolymer science
dc.titleDesign and in vivo evaluation of alginate-based pH-sensing electrospun wound dressing containing anthocyanins
dc.typeArticle
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentMühendislik Fakültesi/Tekstil Mühendisliği
local.contributor.departmentFen Edebiyat Fakültesi/Kimya Bölümü
local.contributor.departmentTıp Fakültesi/Farmakoloji Ana Bilim Dalı
local.contributor.departmentZiraat Fakültesi/Gıda Mühendisliği
local.indexed.at
local.indexed.atWOS

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