Publication:
Prognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey

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dc.contributor.authorÖzbek, Uǧur
dc.contributor.authorSırma, Sema
dc.contributor.authorAğaoğlu, Leyla
dc.contributor.authorYüksel, Lebriz
dc.contributor.authorAnak, Sema
dc.contributor.authorYıldız, İnci
dc.contributor.authorDevecioğlu, Omer
dc.contributor.authorTimur, Çetin
dc.contributor.authorGedikoğlu, Gündüz
dc.contributor.buuauthorMeral, Adalet
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentÇocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.contributor.orcid0000-0002-1201-7542
dc.contributor.orcid0000-0001-5319-0547
dc.contributor.researcheridU-6138-2017
dc.contributor.researcheridC-9513-2017
dc.contributor.scopusid6602571317
dc.date.accessioned2023-03-24T09:45:08Z
dc.date.available2023-03-24T09:45:08Z
dc.date.issued2003-03
dc.description.abstractPurpose: The t(12;21) translocation is the most common reciprocal chromosomal rearrangement in pediatric acute lymphoblastic leukemia (ALL). This translocation fuses two genes, TEL and AML1, and results in the production of the TEL-AML1 fusion protein. The authors investigated the incidence and prognostic significance of the TEL-AML1 fusion gene in patients with ALL in Turkey. Methods: The authors analyzed 219 children with ALL using the reverse transcription-polymerase chain reaction. Results: The TEL-AML1 fusion transcript was detected in 20.1% (44/219) of newly diagnosed children with ALL. TEL-AML1-positive patients had precursor B-cell ALL and were 3 to 10 years old at diagnosis. TEL-AML1-positive patients had a significantly lower rate of relapse compared with TEL-AML1-negative patients. TEL-AML1-positive patients have a higher overall survival rate than TEL-AML1-negative patients. Conclusions: These data support that the presence of TEL-AML1 at diagnosis is an independent favorable prognostic indicator in patients with ALL in Turkey.
dc.identifier.citationÖzbek, U. vd. (2003). “Prognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey”. Journal of Pediatric Hematology Oncology, 25(3), 204-208.
dc.identifier.endpage208
dc.identifier.issn1077-4114
dc.identifier.issue3
dc.identifier.pubmed12621238
dc.identifier.scopus2-s2.0-0037336142
dc.identifier.startpage204
dc.identifier.urihttps://doi.org/10.1097/00043426-200303000-00005
dc.identifier.urihttps://journals.lww.com/jpho-online/fulltext/2003/03000/prognostic_significance_of_the_tel_aml1_fusion.5.aspx
dc.identifier.urihttp://hdl.handle.net/11452/31731
dc.identifier.volume25
dc.identifier.wos000181416800003
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherLippincott Williams and Wilkins
dc.relation.collaborationYurt içi
dc.relation.journalJournal of Pediatric Hematology Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOncology
dc.subjectHematology
dc.subjectPediatrics
dc.subjectAcute lymphoblastic leukemia
dc.subjectPediatric leukemia
dc.subjectTEL-AML1
dc.subjectTEL/AML1 fusion
dc.subjectCryptic t(12-21)
dc.subjectChildhood
dc.subjectChildren
dc.subjectTranscript
dc.subjectFrequency
dc.subjectSubgroup
dc.subjectRelapse
dc.subject.emtreeAcute lymphoblastic leukemia
dc.subject.emtreeArticle
dc.subject.emtreeCancer incidence
dc.subject.emtreeChild
dc.subject.emtreeChildhood leukemia
dc.subject.emtreeClinical feature
dc.subject.emtreeFemale
dc.subject.emtreeFusion gene
dc.subject.emtreeHuman
dc.subject.emtreeImmunophenotyping
dc.subject.emtreeKaplan meier method
dc.subject.emtreeMajor clinical study
dc.subject.emtreeMale
dc.subject.emtreePre b lymphocyte
dc.subject.emtreePriority journal
dc.subject.emtreePrognosis
dc.subject.emtreeReciprocal chromosome translocation
dc.subject.emtreeRelapse
dc.subject.emtreeReverse transcription polymerase chain reaction
dc.subject.emtreeSurvival rate
dc.subject.emtreeTurkey (republic)
dc.subject.emtreeHybrid protein
dc.subject.emtreeTel aml1 protein
dc.subject.emtreeUnclassified drug
dc.subject.meshAdolescent
dc.subject.meshChild
dc.subject.meshChild, preschool
dc.subject.meshCore binding factor alpha 2 subunit
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunophenotyping
dc.subject.meshInfant
dc.subject.meshInfant, newborn
dc.subject.meshLeukemia, lymphocytic, acute
dc.subject.meshMale
dc.subject.meshOncogene proteins, fusion
dc.subject.meshPrognosis
dc.subject.meshSurvival rate
dc.subject.meshTurkey
dc.subject.scopusAcute Lymphoblastic Leukemia; Chromosome 21; Pre B Lymphocyte
dc.subject.wosOncology
dc.subject.wosHematology
dc.subject.wosPediatrics
dc.titlePrognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS

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