Publication:
Efficacy of methanol-water extract of inula helenium root against oxidative dna damage

dc.contributor.authorAybastıer, Önder
dc.contributor.buuauthorAYBASTIER, ÖNDER
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentKimya Bölümü
dc.contributor.orcid0000-0002-0380-1992
dc.contributor.researcheridX-4621-2018
dc.date.accessioned2024-06-04T11:39:28Z
dc.date.available2024-06-04T11:39:28Z
dc.date.issued2021-04
dc.description.abstractOBJECTIVE: To investigate the efficacy of methanol-water extract of Inula helenium root against oxidative DNA damage.METHODS: Antioxidant properties of methanol-water extract of Inula helenium root were revealed by 2,2'-azinobis (3-ethylbenzothiazoline-6-suphonic acid) di-ammonium salt (ABTS), Folin-Ciocalteu and high-performance liquid chromatography (HPLC) methods. The effect against oxidative DNA base damage was determined analyzing oxidative DNA base damage products by GC-MS/MS.RESULTS: The methanol-water extract of Inula helenium root showed good antioxidant capacity [32.20 mg trolox equivalents ( TE) /g dried weight (dw) by ABTS method, 54.53 mg TE/g dw by chromium reducing antioxidant capacity method] and total phenolic content [29.83 mg gallic acid equivalent (GAE) / g dw]. The chlorogenic acid, ferulic acid, rosmarinic acid and caffeic acid were determined in the extract by HPLC. The chlorogenic acid, ferulic acid and Inula helenium root extract were revealed to inhibit the oxidative DNA base damage by GC-MS/MS.CONCLUSION: The studies showed a crucial decrease in the amount of the DNA base damage products when antioxidants were used. The results showed that ferulic acid has better inhibition than chlorogenic acid for DNA oxidation. The methanol-water extract of Inula helenium root was determined to inhibit the oxidative DNA damage.
dc.identifier.doi10.19852/j.cnki.jtcm.20210209.008
dc.identifier.endpage300
dc.identifier.issn0255-2922
dc.identifier.issn1577-7014
dc.identifier.issue2
dc.identifier.pubmed33825410
dc.identifier.startpage293
dc.identifier.urihttps://doi.org/10.19852/j.cnki.jtcm.20210209.008
dc.identifier.urihttps://hdl.handle.net/11452/41729
dc.identifier.volume41
dc.identifier.wos000636562900014
dc.indexed.pubmedPubMed
dc.indexed.pubmedPubMed
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherJournal of Traditional Chinese Medical Sciences
dc.relation.bapOUAP (F)-2013/13
dc.relation.journalJournal of Traditional Chinese Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectInula
dc.subjectDna damage
dc.subjectAntioxidants
dc.subjectPhytochemicals
dc.subjectGas chromatography-mass spectrometry
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectIntegrative & complementary medicine
dc.titleEfficacy of methanol-water extract of inula helenium root against oxidative dna damage
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentFen Edebiyat Fakültesi/Kimya Bölümü
relation.isAuthorOfPublication875c0dc3-9c4b-47a6-8052-c7f44f84fc9b
relation.isAuthorOfPublication.latestForDiscovery875c0dc3-9c4b-47a6-8052-c7f44f84fc9b

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