Publication: The turkish experience of COVID-19 infection in people with NMOSD and MOGAD: A milder course?
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Authors
Authors
Şen, Sedat
Tuncer, Aslı
Özakbaş, Serkan
Uzunköprü, Cihat
Baba, Cavid
Demir, Serkan
Beckmann, Yeşim
Gümüş, Haluk
Arslan, Gökhan
Kılıç, Ahmet Kasım
Advisor
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Elsevier
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Abstract
Background: COVID-19 is a multisystemic infection with variables consequences depending on individual and comorbid conditions. The course and outcomes of COVID-19 during neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD) are not clearly known.Objective/methods: The aim of this study was to examine the features and outcomes of COVID-19 infection in NMOSD and MOGAD patients. The patients' demographic and clinical factors, disease modifying treatment (DMT) used and disease information of COVID-19 infection were recorded. Conditions leading to hospitalization and severe exposure to COVID-19 infection were also analyzed.Results: The study included 63 patients from 25 centers. Thirty-two patients (50.8%) belong to AQP-4 seropositive group, 13 (20.6%) and 18 (28.6%) were in MOG-positive and double-seronegative groups, respectively. Risk factors for severe COVID-19 infection and hospitalization were advanced age, high disability level and the presence of comorbid disease. Disease severity was found to be high in double-seronegative NMOSD and low in MOGAD patients. No statistically significant effect of DMTs on disease severity and hospitalization was found.Conclusion: In NMOSD and MOGAD patients, advanced age, high disability and presence of comorbid disease pose risks for severe COVID-19 infection. There was no direct significant effect of DMTs for COVID-19 infection.
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Keywords
Neuromyelitis optica spectrum disorders, Myelin oligodendrocyte glycoprotein antibody-associated disorders, Disease modifying treatment, Coronavirus, Sars-cov-2, Science & technology, Life sciences & biomedicine, Clinical neurology, Neurosciences & neurology