Demographic and clinical characteristics of patients with autosomal dominant polycystic kidney disease: A single center experience

Abstract

OBJECTIVE: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common hereditary kidney disease. We presented the ADPKD patients who were not undergoing replacement therapy.MATERIAL and METHODS: According to the Turkish Nephrology Society Cystic Kidney Disease Working Group online database, patients with ADPKD were questioned for age, sex, smoking, level of education, hypertension (HT), hematuria, history of urinary stones, urinary infections, and extrarenal history of any cysts. Patients who had undergone kidney replacement therapy and who had a glomerular filtration rate (GFR) less than 30 ml/min were excluded.RESULTS: A total of 93 patients (41 +/- 13 years, 44 female, 49 male) were included. 47% of the patients were current smokers and 72% were on at least one antihypertensive drug. The average GFR was 92 +/- 29 ml/min, and the microalbumin-to-creatinine ratio on spot urine was 18 mg/g. Apart from patients who had kidney cysts, 35% had a history of a liver cyst, 25% had kidney stones and 14% had macroscopic hematuria.CONCLUSION: HT and smoking are frequently seen in early phase of ADPKD. These risk factors have a negative effect on the development of cardiovascular disease and renal prognosis in these patients. Overall, this study showed that aggressive care must be ensured to control these risk factors.