Publication: The ki-67 index and neutrophile-lymphocyte ratio are prognostic factors in patients with low-risk endometrial cancer
dc.contributor.author | Çubukcu, Erdem | |
dc.contributor.author | Şahin, Ahmet Bilgehan | |
dc.contributor.author | Atalay, Fatma Öz | |
dc.contributor.author | Ocak, Birol | |
dc.contributor.author | Özşen, Mine | |
dc.contributor.author | Abakay, Candan Demiröz | |
dc.contributor.author | Özerkan, Kemal | |
dc.contributor.author | Hasanzade, Ulviyya | |
dc.contributor.author | Mesahorlı, Merve | |
dc.contributor.author | Deligönül, Adem | |
dc.contributor.author | Ozan, Hakan | |
dc.contributor.author | Evrensel, Türkkan | |
dc.contributor.buuauthor | ÇUBUKÇU, ERDEM | |
dc.contributor.buuauthor | ŞAHİN, AHMET BİLGEHAN | |
dc.contributor.buuauthor | ÖZ ATALAY, FATMA | |
dc.contributor.buuauthor | OCAK, BİROL | |
dc.contributor.buuauthor | ÖZŞEN, MİNE | |
dc.contributor.buuauthor | DEMİRÖZ ABAKAY, CANDAN | |
dc.contributor.buuauthor | ÖZERKAN, KEMAL | |
dc.contributor.buuauthor | HASANZADE, ULVIYYA | |
dc.contributor.buuauthor | Mesahorlı, Merve | |
dc.contributor.buuauthor | DELİGÖNÜL, ADEM | |
dc.contributor.buuauthor | OZAN, HAKAN | |
dc.contributor.buuauthor | EVRENSEL, TÜRKKAN | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Jinekolojik Onkoloji Anabilim Dalı. | |
dc.contributor.orcid | 0000-0002-7846-0870 | |
dc.contributor.orcid | 0000-0001-7537-1699 | |
dc.contributor.orcid | 0000-0002-5771-7649 | |
dc.contributor.orcid | 0000-0001-5380-5898 | |
dc.contributor.researcherid | AAH-9791-2021 | |
dc.contributor.researcherid | K-2269-2016 | |
dc.contributor.researcherid | AAM-4927-2020 | |
dc.contributor.researcherid | ETP-1691-2022 | |
dc.contributor.researcherid | JHC-4482-2023 | |
dc.contributor.researcherid | HHA-1866-2022 | |
dc.contributor.researcherid | AAI-1609-2021 | |
dc.contributor.researcherid | AAH-3855-2021 | |
dc.contributor.researcherid | EXU-7466-2022 | |
dc.contributor.researcherid | FNB-4540-2022 | |
dc.contributor.researcherid | ESM-4544-2022 | |
dc.contributor.researcherid | DKZ-4159-2022 | |
dc.contributor.researcherid | EXJ-0967-2022 | |
dc.date.accessioned | 2024-06-25T11:31:50Z | |
dc.date.available | 2024-06-25T11:31:50Z | |
dc.date.issued | 2021-04-21 | |
dc.description.abstract | Objective: To investigate the prognostic factors comparing clinical, histopathological, and laboratory parameters in low-risk endometrial cancer (EC). Methods: In the present single-center study, multivariate Cox regression analysis was performed on retrospective clinical and laboratory data and histopathological features obtained from the re-evaluation of 253 patients with low-risk EC. Receiver operating characteristic curves (ROC) were plotted for neutrophile-lymphocyte ratio (NLR), platelet-lymphocyte ratio, lymphocyte-monocyte ratio and Ki-67 index for recurrence. Kaplan-Meier analysis was employed for survival rates. Results: The median age was 58.5 years (32.0-75.4). Most of the patients were obese and post-menopausal. In nearly half of the patients, lymphadenectomy was performed in addition to hysterectomy and oophorectomy. The median tumor size was 30 mm (range 2-80), and the median Ki-67 index was 25 (1-90). According to the ROC curve analysis, the cut-off values for the Ki-67 index, NLR, PLR, and LMR were determined as >= 22, >= 1.98, >= 115.3, and >= 4.71, respectively. The log-rank test revealed that the patients with a Ki67 index lower than 22% and NLR lower than 1.98 had statistically longer recurrence-free survival (RFS) (p = 0.002 for Ki-67 index and p = 0.004 for NLR). The multivariate analysis revealed that the Ki-67 index and NLR were statistically significant factors for RFS (p = 0.012 and p = 0.029, respectively). Conclusion: The present study highlights the prognostic implications of both the Ki-67 index and NLR in lowrisk EC. | |
dc.identifier.doi | 10.31083/j.ejgo4204117 | |
dc.identifier.eissn | 2709-0086 | |
dc.identifier.endpage | 781 | |
dc.identifier.issn | 0392-2936 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 775 | |
dc.identifier.uri | https://doi.org/10.31083/j.ejgo4204117 | |
dc.identifier.uri | https://www.ejgo.net/articles/10.31083/j.ejgo4204117 | |
dc.identifier.uri | https://hdl.handle.net/11452/42369 | |
dc.identifier.volume | 42 | |
dc.identifier.wos | 000686639400024 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Mre Press | |
dc.relation.journal | European Journal of Gynaecological Oncology | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Cell proliferation | |
dc.subject | Expression | |
dc.subject | Impact | |
dc.subject | Roles | |
dc.subject | Ki67 | |
dc.subject | P53 | |
dc.subject | PR | |
dc.subject | ER | |
dc.subject | Endometrial cancer | |
dc.subject | Low-risk | |
dc.subject | Ki-67 | |
dc.subject | NLR | |
dc.subject | Survival | |
dc.subject | Oncology | |
dc.subject | Obstetrics & gynecology | |
dc.title | The ki-67 index and neutrophile-lymphocyte ratio are prognostic factors in patients with low-risk endometrial cancer | |
dc.type | Article | |
dspace.entity.type | Publication | |
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