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Structural and neurochemical evaluation of the brain and pons in patients with Wilson's disease

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dc.contributor.authorAlgın, Oktay
dc.contributor.buuauthorTaşkapılıoğlu, Özlem
dc.contributor.buuauthorHakyemez, Bahattin
dc.contributor.buuauthorOcakoğlu, Gökhan
dc.contributor.buuauthorYurtoğulları, Şükran
dc.contributor.buuauthorErer Özbek, Sevda
dc.contributor.buuauthorParlak, Müfit
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentBiyoistatistik Ana Bilim Dalı
dc.contributor.departmentNöroloji Ana Bilim Dalı
dc.contributor.departmentRadyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-3425-0740
dc.contributor.researcheridAAI-2318-2021
dc.contributor.researcheridAAG-8521-2021
dc.contributor.researcheridAAK-6623-2020
dc.contributor.researcheridAAH-5180-2021
dc.contributor.scopusid23037226400
dc.contributor.scopusid6602527239
dc.contributor.scopusid15832295800
dc.contributor.scopusid36873746200
dc.contributor.scopusid25635370800
dc.contributor.scopusid7003589220
dc.date.accessioned2022-03-14T13:24:35Z
dc.date.available2022-03-14T13:24:35Z
dc.date.issued2010-11
dc.description.abstractThe aim of this study was to examine the structural-neurochemical abnormalities of the frontal white matter (FWM), deep gray matter nuclei, and pons in patients with Wilson's disease (WD) using proton magnetic resonance spectroscopy (MRS) and diffusion-weighted imaging (DWI). Nine patients with WD and 14 age-matched controls were examined with MRS. N-Acetylaspartate (NAA), choline (Cho), and creatine (Cr) peaks were calculated. DWI scans from six WD patients and six controls were also obtained. The relative metabolite ratios and apparent diffusion coefficient (ADC) values of the WD patients were compared to those of the control subjects by using statistical measures. Measurements in the thalamus and pons showed significantly lower NAA/Cho and NAA/Cr ratios in the WD group than in the control group (P < 0.05). Thalamic and pontine Cho/Cr ratios in the patient group were significantly higher than those of the control group (P < 0.05). No statistically significant relation was found between the patient and control groups as a result of the MRS examinations of FWM and all ADC measurements (P > 0.05). MRS is a noninvasive, valuable modality for detecting structural-neurochemical changes of the brain stem and deep gray matter in patients with WD. The contribution of DWI in these patients is limited.
dc.identifier.citationAlgın, O. vd. (2010). "Structural and neurochemical evaluation of the brain and pons in patients with Wilson's disease". Japanese Journal of Radiology, 28(9), 663-671.
dc.identifier.doi10.1007/s11604-010-0491-4
dc.identifier.endpage671
dc.identifier.issn1867-1071
dc.identifier.issn1867-108X
dc.identifier.issue9
dc.identifier.pubmed21113750
dc.identifier.scopus2-s2.0-79953322680
dc.identifier.startpage663
dc.identifier.urihttps://doi.org/10.1007/s11604-010-0491-4
dc.identifier.urihttps://link.springer.com/article/10.1007/s11604-010-0491-4
dc.identifier.urihttp://hdl.handle.net/11452/25009
dc.identifier.volume28
dc.identifier.wos000284645900005
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherSpringer
dc.relation.collaborationSanayi
dc.relation.journalJapanese Journal of Radiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectWilson's disease
dc.subjectProton MR spectroscopy
dc.subjectNeuroimaging
dc.subjectDiffusion magnetic resonance imaging
dc.subjectNeuronal loss
dc.subjectKayser-Fleischer rings
dc.subjectClinical correlation
dc.subjectDiffusion
dc.subjectRadiology, nuclear medicine & medical imaging
dc.subject.emtreeAspartic acid
dc.subject.emtreeCholine
dc.subject.emtreeCreatine
dc.subject.emtreeDrug derivative
dc.subject.emtreeN acetylaspartic acid
dc.subject.emtreeN-acetylaspartate
dc.subject.emtreeAdult
dc.subject.emtreeArticle
dc.subject.emtreeBrain
dc.subject.emtreeDiffusion weighted imaging
dc.subject.emtreeFemale
dc.subject.emtreeHuman
dc.subject.emtreeMale
dc.subject.emtreeMetabolism
dc.subject.emtreeMethodology
dc.subject.emtreeMiddle aged
dc.subject.emtreeNeurochemistry
dc.subject.emtreeNuclear magnetic resonance spectroscopy
dc.subject.emtreePathology
dc.subject.emtreePons
dc.subject.emtreeScintiscanning
dc.subject.emtreeWilson disease
dc.subject.meshAdult
dc.subject.meshAspartic acid
dc.subject.meshBrain
dc.subject.meshCholine
dc.subject.meshCreatin
dc.subject.meshDiffusion magnetic resonance imaging
dc.subject.meshFemale
dc.subject.meshHepatolenticular degeneration
dc.subject.meshHumans
dc.subject.meshMagnetic resonance spectroscopy
dc.subject.meshMale
dc.subject.meshMiddle aged
dc.subject.meshNeurochemistry
dc.subject.meshPons
dc.subject.meshYoung adult
dc.subject.scopusHepatolenticular Degeneration; Copper-transporting ATPases; Penicillamine
dc.subject.wosRadiology, nuclear medicine & medical imaging
dc.titleStructural and neurochemical evaluation of the brain and pons in patients with Wilson's disease
dc.typeArticle
dc.wos.quartileQ4
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Nöroloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Radyoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Biyoistatistik Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

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