Publication:
Evaluation of platelet count and its association with plateletcrit, mean platelet volume, and platelet size distribution width in a canine model of endotoxemia

dc.contributor.buuauthorYılmaz, Zeki
dc.contributor.buuauthorEralp, Oya
dc.contributor.buuauthorİlçöl, Yeşim Özarda
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentVeteriner Fakültesi
dc.contributor.departmentİç Hastalıkları Ana Bilim Dalı
dc.contributor.departmentBiyokimya Ana Bilim Dalı
dc.contributor.orcid0000-0002-4242-8609
dc.contributor.orcid0000-0001-9836-0749
dc.contributor.researcheridAAL-8873-2021
dc.contributor.researcheridAAG-2943-2020
dc.contributor.scopusid35944810500
dc.contributor.scopusid24472964600
dc.contributor.scopusid35741320500
dc.date.accessioned2021-12-01T08:32:31Z
dc.date.available2021-12-01T08:32:31Z
dc.date.issued2008-06
dc.description.abstractBackground: Platelets are of great importance in the pathogenesis of endotoxemia. Although thrombocytopenia is used as a diagnostic sign of endotoxemia, changes in values for platelet indices (plateletcrit [PCT], mean platelet volume [MPV], and platelet size distribution width [PDW]) in response to endotoxin are still unknown. Objective: The aim of this study was to evaluate platelet count and its relations with platelet indices in a canine model of endotoxemia. Methods: Twenty dogs were divided into 2 groups of 10 each, and treated intravenously with Escherichia coli endotoxin (1 mg/kg) or vehicle. Venous blood samples were collected before treatment (0 hour) and 0.5, 1, 2, 4, 6, 8, 12, and 24 hours after treatment. Platelet counts and indices were determined on a CELL-DYN hematology analyzer. Results: The platelet count and PCT decreased by a mean of 73% and 93%, respectively (P <.001), at 0.5 hour, and remained 70% and 85% lower than baseline values (P <.001) for 24 hours after endotoxin injection. MPV and PDW increased by a mean of 28% and 45%, respectively (P <.01), at 0.5 hour, and remained increased by 7% and 16% over baseline values for 24 hours (P <.01-.001). Platelet count correlated positively with PCT (P <.001), but correlated negatively with MPV (P <.001) and PDW (P <.01). Conclusions: Changes in platelet count and its association with platelet indices may reflect changes in platelet production and reactivity. Platelet indices have potential value in the diagnosis and monitoring of dogs and humans with endotoxemia.
dc.identifier.citationYılmaz, Z. vd. (2008). ''Evaluation of platelet count and its association with plateletcrit, mean platelet volume, and platelet size distribution width in a canine model of endotoxemia''. Veterinary Clinical Pathology, 37(2), 159-163.
dc.identifier.endpage163
dc.identifier.issn0275-6382
dc.identifier.issn1939-165X
dc.identifier.issue2
dc.identifier.pubmed18533914
dc.identifier.scopus2-s2.0-47649122356
dc.identifier.startpage159
dc.identifier.urihttps://doi.org/10.1111/j.1939-165X.2008.00023.x
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/j.1939-165X.2008.00023.x
dc.identifier.urihttp://hdl.handle.net/11452/22926
dc.identifier.volume37
dc.identifier.wos000256413500005
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherWiley
dc.relation.journalVeterinary Clinical Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectVeterinary sciences
dc.subjectCanis familiaris
dc.subjectEscherichia coli
dc.subjectMoroccan pepper virus
dc.subjectDog
dc.subjectEndotoxin
dc.subjectMpv
dc.subjectPct
dc.subjectPdw
dc.subjectPlatelet
dc.subjectSepsis
dc.subjectDogs
dc.subjectNumber
dc.subjectDys
dc.subjectFunction
dc.subjectDiagnosis
dc.subject.emtreeLipopolysaccharide
dc.subject.emtreeLipopolysaccharide, e coli O55 B5
dc.subject.emtreeAnimal
dc.subject.emtreeAnimal disease
dc.subject.emtreeArticle
dc.subject.emtreeBlood
dc.subject.emtreeChemically induced disorder
dc.subject.emtreeCytology
dc.subject.emtreeDog
dc.subject.emtreeDog disease
dc.subject.emtreeEndotoxemia
dc.subject.emtreeFemale
dc.subject.emtreeMale
dc.subject.emtreeThrombocyte
dc.subject.emtreeThrombocyte count
dc.subject.emtreeTime
dc.subject.meshAnimals
dc.subject.meshBlood Platelets
dc.subject.meshDog Diseases
dc.subject.meshDogs
dc.subject.meshEndotoxemia
dc.subject.meshFemale
dc.subject.meshLipopolysaccharides
dc.subject.meshMale
dc.subject.meshPlatelet Count
dc.subject.meshTime Factors
dc.subject.scopusMean Platelet Volume; Blood Platelets; Erythrocyte Indices
dc.subject.wosVeterinary sciences
dc.titleEvaluation of platelet count and its association with plateletcrit, mean platelet volume, and platelet size distribution width in a canine model of endotoxemia
dc.typeArticle
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentVeteriner Fakültesi/İç Hastalıkları Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Biyokimya Ana Bilim Dalı
local.indexed.atWOS
local.indexed.atScopus

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Yılmaz_vd_2008.pdf
Size:
112.99 KB
Format:
Adobe Portable Document Format
Description:

License bundle

Now showing 1 - 1 of 1
Placeholder
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: