Yayın:
Comparative analysis of HER-2/neu amplification, overexpression and polysomy 17 in patients with metastatic breast cancer

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dc.contributor.authorYakut, T.
dc.contributor.authorDemiray, M.
dc.contributor.authorGülten, T.
dc.contributor.authorErcan, I.
dc.contributor.authorHatipoǧlu, M.
dc.contributor.authorYiǧit, B.
dc.contributor.authorTolunay, S.
dc.contributor.buuauthorYakut, Tahsin
dc.contributor.buuauthorDemiray, Mutlu
dc.contributor.buuauthorGülten, Tuna
dc.contributor.buuauthorERCAN, İLKER
dc.contributor.buuauthorHatipoǧlu, Mustafa
dc.contributor.buuauthorYiǧit, Barboros
dc.contributor.buuauthorTOLUNAY, ŞAHSİNE
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıbbi Genetik Ana Bilim Dalı
dc.contributor.departmentOnkoloji Ana Bilim Dalı
dc.contributor.departmentBiyoistatistik Ana Bilim Dalı
dc.contributor.departmentPatoloji Ana Bilim Dalı
dc.contributor.departmentMedikal Genetik Bölümü
dc.contributor.orcid0000-0002-8661-6126
dc.contributor.orcid0000-0002-2382-290X
dc.contributor.scopusid6602802424
dc.contributor.scopusid6603631569
dc.contributor.scopusid6505944216
dc.contributor.scopusid6603789069
dc.contributor.scopusid56140589700
dc.contributor.scopusid8412409600
dc.date.accessioned2025-08-06T23:55:53Z
dc.date.issued2006-05-16
dc.description.abstractAmplification or overexpression of HER-2/neu oncogene is associated with poor prognosis and has been correlated with the response to trastuzumab treatment. Chromosomal copy number changes of chromosome 17 occurs in breast cancers and effect the copy number of HER-2/neu gene and consequently IHC score relatively. The aim of this study was to investigate the contribution of chromosome 17 polysomy to positive HER-2/neu immunostaining independent of HER-2/neu amplification using dual-color FISH technique on the paraffin-embedded tissues of metastatic breast cancers. Paraffin-embedded speciment of 32 metastatic breast cancer cases were analysed using dual-color FISH probes specific to HER-2/neu gene and chromosome 17. Results showed significant association between the cases with IHC 2+ and polysomy 17 (p=0.011), and IHC 3+ and HER-2/neu amplification (p=0.023). In conclusion, increased HER-2/neu gene copy number in accordance with polysomy 17 might lead to a strong protein overexpression in the metastatic breast cancer. Therefore FISH technique may also be more sensitive interpretation tool in cases with polysomy 17.
dc.identifier.endpage8
dc.identifier.issn1306-133X
dc.identifier.issue1
dc.identifier.scopus2-s2.0-33646461921
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/11452/54195
dc.identifier.volume16
dc.indexed.scopusScopus
dc.language.isoen
dc.relation.journalUhod Uluslararasi Hematoloji Onkoloji Dergisi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMetastatic breast cancers
dc.subjectIHC
dc.subjectHER-2/neu
dc.subjectFISH
dc.titleComparative analysis of HER-2/neu amplification, overexpression and polysomy 17 in patients with metastatic breast cancer
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Genetik Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Onkoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Biyoistatistik Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Patoloji Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Medikal Genetik Bölümü
local.indexed.atScopus
relation.isAuthorOfPublication50e4dfdb-25cd-43af-94c9-464881669605
relation.isAuthorOfPublication13dc6562-e9fe-42fa-8973-dcd80444844e
relation.isAuthorOfPublication.latestForDiscovery50e4dfdb-25cd-43af-94c9-464881669605

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